Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 4/20 | 0.88 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.88 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levomenthol SCHEMBL2954662 | 1.00 | TRPM8 (0.88) | TRPM8TRPA1EPHX1ALDH1A1TRPV1 | |
| Menthol SCHEMBL27696394 | 0.98 | TRPM8 (0.84) | TRPM8TRPA1EPHX1ALDH1A1TRPV1 | |
| (+)-Menthol SCHEMBL15449169 | 0.94 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1TRPV1 | |
| (+)-Menthol SCHEMBL13059620 | 0.94 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1TRPV1 | |
| (+)-Menthol SCHEMBL1709231 | 0.94 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1TRPV1 | |
| (+)-Menthol SCHEMBL9968934 | 0.94 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1TRPV1 | |
| (+)-Menthol SCHEMBL12646785 | 0.94 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1TRPV1 | |
| Racementhol SCHEMBL521946 | 0.94 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1TRPV1 | |
| Menthol SCHEMBL20771511 | 0.94 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1TRPV1 | |
| (+) Neomenthol SCHEMBL260049 | 0.94 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1067 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110869365-B | Cooling composition | 弗门尼舍有限公司 | 2024-03-29 | — | — | CN | claimed |
| US-20240000746-A1 | New Cooling Agents and Preparations Containing Them | SYMRISE AG (DE) | 2024-01-04 | — | — | US | claimed |
| CN-112645803-B | Synthetic method of menthol methyl ether | 厦门中坤化学有限公司 | 2023-10-20 | — | — | CN | claimed |
| EP-4247791-A2 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | Symrise AG (DE) | 2023-09-27 | — | — | EP | claimed |
| CN-116685575-A | Novel cooling substances and formulations containing these cooling substances | 西姆莱斯股份公司 | 2023-09-01 | — | — | CN | claimed |
| WO-2023143741-A1 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | SYMRISE AG (DE) | 2023-08-03 | — | — | WO | claimed |
| WO-2023144326-A1 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | SYMRISE AG (DE) | 2023-08-03 | — | — | WO | claimed |
| WO-2023117119-A1 | ACTIVE INGREDIENTS WITH SIALAGOGUE AND TINGLING/FIZZY EFFECT, AND PREPARATIONS CONTAINING SAME | SYMRISE AG (DE) | 2023-06-29 | — | — | WO | claimed |
| EP-4015075-A1 | STANDARD PACKAGES WITH FIXED COOLING MATERIALS | Symrise AG (DE) | 2022-06-22 | — | — | EP | claimed |
| WO-2022106452-A2 | NEW COOLANTS, AND PREPARATIONS CONTAINING SAME | SYMRISE AG (DE) | 2022-05-27 | — | — | WO | claimed |
| US-20040253278-A1 | Breath Freshening and Oral Cleansing Product Using Carvacrol | WM WRIGLEY JR. COMPANY | 2004-12-16 | — | — | US | claimed |
| US-20040253192-A1 | Breath Freshening and Oral Cleansing Product Using Cardamom Oil | WM. WRIGLEY JR. COMPANY | 2004-12-16 | — | — | US | claimed |
| US-20040253191-A1 | Breath Freshening and Oral Cleansing Product | WM. WRIGLEY JR. COMPANY | 2004-12-16 | — | — | US | claimed |
| US-20040253190-A1 | Breath Freshening and Oral Cleansing Product Using Citral | WM. WRIGLEY JR. COMPANY | 2004-12-16 | — | — | US | claimed |
| WO-2004019867-A2 | BREATH FRESHENING AND ORAL CLEANSING PRODUCT USING CARDAMOM OIL | WM. WRIGLEY JR. COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| WO-2004019800-A2 | BREATH FRESHENING AND ORAL CLEANSING PRODUCT | WM. WRIGLEY JR. COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| WO-2004019922-A1 | BREATH FRESHENING AND ORAL CLEANSING PRODUCT USING CITRAL | WM. WRIGLEY JR. COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| WO-2004019870-A2 | BREATH FRESHENING AND ORAL CLEANSING PRODUCT USING SALICYLALDEHYDE | WM. WRIGLEY JR. COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| WO-2004019802-A2 | BREATH FRESHENING AND ORAL CLEANSING PRODUCT USING CARVACROL | WM. WRIGLEY JR. COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| WO-2004019871-A2 | BREATH FRESHENING AND ORAL CLEANSING PRODUCT USING GERANIOL | WM. WRIGLEY JR. COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240000746-A1 | New Cooling Agents and Preparations Containing Them | TTPA, TREH, TAS2R45 | TRPM8 132/4885TRPA1 313/4885EPHX1 1993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.