Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11523126 | 0.81 | STIM1 (0.45) | NPC1ALDH1A1KDM4EMAPTGHSR | |
| SCHEMBL11520929 | 0.80 | MAPT (0.51) | NPC1ALDH1A1KDM4EMAPK1MAPT | |
| SCHEMBL11522756 | 0.80 | KDM4E (0.48) | NPC1ALDH1A1KDM4EMAPK1MAPT | |
| SCHEMBL11522456 | 0.79 | KDM4E (0.51) | NPC1ALDH1A1KDM4EMAPK1MAPT | |
| SCHEMBL4060750 | 0.79 | POLB (0.50) | RAB9ATYK2JAK2JAK1 | |
| SCHEMBL11526321 | 0.78 | STIM1 (0.42) | NPC1ALDH1A1MAPTGHSRRAB9A | |
| SCHEMBL11524573 | 0.77 | RAB9A (0.46) | NPC1MAPTGHSRRAB9ANPSR1 | |
| SCHEMBL11522661 | 0.76 | IL2 (0.42) | NPC1ALDH1A1MAPTRAB9ATP53 | |
| SCHEMBL8659373 | 0.75 | NPSR1 (0.43) | NPC1ALDH1A1KDM4EMAPTGHSR | |
| SCHEMBL11519411 | 0.74 | RAB9A (0.47) | NPC1KDM4EMAPTGHSRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |