SCHEMBL11527293

SCHEMBL11527293

Cc1nc(-c2ccc(C(=O)Cl)cc2)oc1C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.49
ALDH1A1 P00352 2/20 0.46
LMNA P02545 1/20 0.46
GAA P10253 2/20 0.44
TARBP2 Q15633 5/20 0.43
IKBKB O14920 4/20 0.43
HDAC6 Q9UBN7 1/20 0.41
POLB P06746 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
SMO Q99835 1/20 0.40
PDCD4 Q53EL6 1/20 0.40
MAPT P10636 2/20 0.39
NPC1 O15118 1/20 0.39
HPGD P15428 1/20 0.39
NFKB1 P19838 1/20 0.39
RAB9A P51151 1/20 0.39
NFKB2 Q00653 1/20 0.39
RELA Q04206 1/20 0.39
ATM Q13315 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL505227 0.85 RAB9A (0.53) KDM4EALDH1A1LMNAGAATARBP2
SCHEMBL11524334 0.81 GAA (0.46) KDM4EALDH1A1LMNAGAAIKBKB
SCHEMBL505624 0.81 ALDH1A1 (0.61) KDM4EALDH1A1LMNAGAATARBP2
SCHEMBL9862893 0.77 NPC1 (0.51) KDM4EGAAHDAC6MAPTNPC1
SCHEMBL5534902 0.77 KDM4E (0.59) KDM4EALDH1A1LMNAGAATARBP2
SCHEMBL2706143 0.76 NPC1 (0.52) KDM4EALDH1A1LMNATARBP2IKBKB
SCHEMBL11525019 0.76 IKBKB (0.41) KDM4EALDH1A1LMNATARBP2IKBKB
SCHEMBL461441 0.75 NPC1 (0.49) KDM4EHDAC6NPC1RAB9A
SCHEMBL11524472 0.75 RAB9A (0.58) KDM4EALDH1A1GAAHDAC6POLB
SCHEMBL11330689 0.74 SMN1; SMN2 (0.60) KDM4EALDH1A1LMNAGAAHDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4159985-A Heterocyclic phenyl ester ultraviolet stabilizers EASTMAN KODAK COMPANY (US) 1979-07-03 US disclosed
US-4140674-A FOR POLYMERS EASTMAN KODAK COMPANY (US) 1979-02-20 US disclosed
US-4020080-A Oxadiazolylphenyl aromatic ester compounds and their use as ultraviolet stabilizer in organic compositions EASTMAN KODAK COMPANY (US) 1977-04-26 US disclosed