SCHEMBL11529368

SCHEMBL11529368

CCCC(=O)OCC1=C(COC(=O)CCC)C2C=CC1C2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NLRP3 Q96P20 2/20 0.42
ALDH1A1 P00352 5/20 0.38
DGKA P23743 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
HPGD P15428 1/20 0.32
CYP2C19 P33261 1/20 0.32
ELANE P08246 2/20 0.31
MEN1 O00255 1/20 0.31
NPC1 O15118 1/20 0.31
POLB P06746 1/20 0.31
MAPT P10636 1/20 0.31
RAB9A P51151 1/20 0.31
KMT2A Q03164 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
TDP1 Q9NUW8 2/20 0.31
USP2 O75604 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11529890 0.86 ALDH1A1 (0.38) ALDH1A1CYP1A2HPGDCYP2C19KMT2A
SCHEMBL11527904 0.78 ALDH1A1 (0.42) NLRP3ALDH1A1CYP1A2CYP3A4HPGD
SCHEMBL11526100 0.77 ALDH1A1 (0.34) ALDH1A1CYP1A2HPGDCYP2C19
SCHEMBL11528557 0.76 NLRP3 (0.41) NLRP3ALDH1A1
SCHEMBL11529960 0.75 TDP1 (0.45) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL11525262 0.69 ALDH1A1 (0.38) NLRP3ALDH1A1CYP3A4CYP2C19ALOX15
SCHEMBL9129929 0.67 ALDH1A1 (0.43) NLRP3ALDH1A1DGKAELANEMEN1
SCHEMBL1870004 0.66 ALDH1A1 (0.63) ALDH1A1CYP3A4HPGDCYP2C19MEN1
SCHEMBL22435386 0.66 MEN1 (0.53) ALDH1A1CYP1A2CYP2D6CYP2C19MEN1
SCHEMBL19960 0.66 ALDH1A1 (0.63) ALDH1A1CYP3A4HPGDCYP2C19MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4132750-A RING OPENING POLYMERIZATION OF NORBORNENE DERIVATIVES SHOWA DENKO K.K. (JP) 1979-01-02 US disclosed
US-4080491-A CATALYST CONTAINS ORGANOMETALLIC COMPOUND AND THE REACTION PRODUCT OF TUNGSTEN OR MOLYBDENUM OXIDE AND A PHOSPHOROUS HALIDE OR OXYHALIDE SHOWA DENKO K.K. (JA) 1978-03-21 US disclosed
US-4028482-A LOW VISCOSITY POLYALKENAMER SHOWA DENKO KABUSHIKI KAISHA (JA) 1977-06-07 US disclosed
US-3959234-A CATALYSTS OF ORGANOALUMINUM COMPOUNDS AND A TUNGSTEN OR MOLYBDENUM COMPOUND, RING-OPENING SHOWA DENKO KABUSHIKI KAISHA (JA) 1976-05-25 US disclosed