Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.76 |
| ▸ | HTR1A | P08908 | 1/20 | 0.76 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.76 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.76 |
| ▸ | DRD2 | P14416 | 1/20 | 0.76 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.76 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.76 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.76 |
| ▸ | DRD4 | P21917 | 1/20 | 0.76 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.76 |
| ▸ | HRH2 | P25021 | 1/20 | 0.76 |
| ▸ | HTR2A | P28223 | 1/20 | 0.76 |
| ▸ | HTR2C | P28335 | 1/20 | 0.76 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.76 |
| ▸ | HRH1 | P35367 | 1/20 | 0.76 |
| ▸ | DRD3 | P35462 | 1/20 | 0.76 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.76 |
| ▸ | HTR2B | P41595 | 1/20 | 0.76 |
| ▸ | HTR5A | P47898 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11533022 | 0.93 | HTR6 (0.64) | CHRM2HTR1ACHRM5ADRA2ADRD2 | |
| SCHEMBL11891460 | 0.86 | HTR6 (1.00) | CHRM2HTR1ACHRM5ADRA2ADRD2 | |
| Iprindole SCHEMBL49509 | 0.86 | HTR6 (1.00) | CHRM2HTR1ACHRM5ADRA2ADRD2 | |
| Iprindole SCHEMBL29407410 | 0.86 | HTR6 (1.00) | CHRM2HTR1ACHRM5ADRA2ADRD2 | |
| Iprindole SCHEMBL5705755 | 0.85 | HTR6 (0.97) | CHRM2HTR1ACHRM5ADRA2ADRD2 | |
| SCHEMBL11531250 | 0.82 | HTR6 (0.52) | CHRM2HTR1ACHRM5ADRA2ADRD2 | |
| SCHEMBL11531885 | 0.79 | CHRM2 (0.72) | CHRM2HTR1ACHRM5ADRA2ADRD2 | |
| SCHEMBL25818911 | 0.78 | HTR6 (0.85) | CHRM2HTR1ACHRM5ADRA2ADRD2 | |
| SCHEMBL7411149 | 0.77 | HTR6 (0.66) | CHRM2HTR1ACHRM5ADRA2ADRD2 | |
| SCHEMBL7410052 | 0.76 | DRD2 (0.65) | CHRM2HTR1ACHRM5ADRA2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4144349-A | N,N-dimethyl-1,2,4,5,6,7-hexahydrothiocino[5,4-b]-indole-7-propanamine-3,3-dioxides and related thiocines | WARNER-LAMBERT COMPANY (US) | 1979-03-13 | — | — | US | claimed |
| US-4144349-A | N,N-dimethyl-1,2,4,5,6,7-hexahydrothiocino[5,4-b]-indole-7-propanamine-3,3-dioxides and related thiocines | WARNER-LAMBERT COMPANY (US) | 1979-03-13 | — | — | US | disclosed |