Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Ambroxol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.87 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.87 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.87 |
| ▸ | LMNA | P02545 | 2/20 | 0.87 |
| ▸ | GBA1 | P04062 | 1/20 | 0.87 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.87 |
| ▸ | CNR1 | P21554 | 1/20 | 0.87 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.87 |
| ▸ | HRH2 | P25021 | 1/20 | 0.87 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.85 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.85 |
| ▸ | TSHR | P16473 | 1/20 | 0.85 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.85 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ambroxol SCHEMBL423712 | 0.93 | CYP2D6 (1.00) | CYP2D6SLC6A4KCNH2LMNAGBA1 | |
| Ambroxol SCHEMBL28472066 | 0.93 | CYP2D6 (1.00) | CYP2D6SLC6A4KCNH2LMNAGBA1 | |
| Ambroxol SCHEMBL18702 | 0.93 | CYP2D6 (1.00) | CYP2D6SLC6A4KCNH2LMNAGBA1 | |
| Ambroxol SCHEMBL29380194 | 0.93 | CYP2D6 (1.00) | CYP2D6SLC6A4KCNH2LMNAGBA1 | |
| Ambroxol SCHEMBL7855003 | 0.93 | CYP2D6 (1.00) | CYP2D6SLC6A4KCNH2LMNAGBA1 | |
| Ambroxol SCHEMBL6601413 | 0.92 | CYP3A4 (1.00) | CYP2D6SLC6A4KCNH2LMNAGBA1 | |
| Ambroxol SCHEMBL99455 | 0.92 | CYP3A4 (1.00) | CYP2D6SLC6A4KCNH2LMNAGBA1 | |
| Ambroxol SCHEMBL1648757 | 0.91 | CYP2D6 (0.94) | CYP2D6SLC6A4KCNH2LMNAGBA1 | |
| Ambroxol SCHEMBL1230755 | 0.88 | CYP2D6 (0.83) | CYP2D6SLC6A4KCNH2LMNAGBA1 | |
| SCHEMBL24446418 | 0.85 | CYP2D6 (0.84) | CYP2D6SLC6A4KCNH2LMNAGBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4138351-A | Electrophoretic liquid developer containing a metal alkyl sulphonate | AGFA-GEVAERT N.V. (BE) | 1979-02-06 | — | — | US | disclosed |