Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11569730 | 0.87 | ALDH1A1 (0.37) | HPGDHTTALDH1A1NPC1PPARG | |
| SCHEMBL11534203 | 0.76 | MEN1 (0.45) | HTTALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL28808246 | 0.74 | ALDH1A1 (0.36) | HPGDHTTALDH1A1NPC1PPARG | |
| SCHEMBL11664943 | 0.72 | NPC1 (0.31) | HTTALDH1A1NPC1PPARGRAB9A | |
| SCHEMBL11535382 | 0.71 | POLB (0.44) | HPGDHTTALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL4574399 | 0.70 | HPGD (0.34) | HPGDHTTALDH1A1NPC1PPARG | |
| SCHEMBL4573400 | 0.69 | ALDH1A1 (0.32) | HPGDHTTALDH1A1NPC1PPARG | |
| SCHEMBL7288669 | 0.68 | HTT (0.41) | HPGDHTTALDH1A1NPC1PPARG | |
| SCHEMBL11608520 | 0.68 | ALDH1A1 (0.38) | HTTALDH1A1NPC1PPARGRAB9A | |
| SCHEMBL28326509 | 0.68 | HTT (0.33) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154734-A | Amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide | WARNER-LAMBERT COMPANY (US) | 1979-05-15 | — | — | US | disclosed |
| US-4134896-A | 5,6-Dihydro-4-oxo-4H-thieno[2,3-b]thiopyran-5-carboxamides, and process for the preparation thereof | WARNER-LAMBERT COMPANY (US) | 1979-01-16 | — | — | US | disclosed |
| US-4134897-A | Amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide and process for the preparation thereof | WARNER-LAMBERT COMPANY (US) | 1979-01-16 | — | — | US | disclosed |
| US-4134900-A | 5,6-Dihydro-4-oxo-4H-thieno[2,3-b]thiopyran-5-carboxamides, and process for the preparation thereof | WARNER-LAMBERT COMPANY (US) | 1979-01-16 | — | — | US | disclosed |
| US-4127585-A | Isoxazol amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide | WARNER-LAMBERT COMPANY (US) | 1978-11-28 | — | — | US | disclosed |
| US-4098794-A | N-Thiazolyl-5,6-dihydro-4-oxo-4H-thieno[2,3-b]thiopyran-5-carboxamides | WARNER-LAMBERT COMPANY (US) | 1978-07-04 | — | — | US | disclosed |
| US-4097441-A | 5,6-Dihydro-4-oxo-4H-thieno 2,3-b!thiopyran-5-carboxamides | WARNER-LAMBERT COMPANY (US) | 1978-06-27 | — | — | US | disclosed |
| US-4092325-A | 5,6-Dihydro-4-oxo-4H-thieno[2,3-b]thiopyran-5-carboxamides, and process for the preparation thereof | WARNER-LAMBERT COMPANY (US) | 1978-05-30 | — | — | US | disclosed |
| US-4082757-A | Amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide | WARNER-LAMBERT COMPANY (US) | 1978-04-04 | — | — | US | disclosed |