Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.39 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.35 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.35 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.35 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.35 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.35 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.35 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.35 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.35 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.35 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.35 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL11533801 | 1.00 | KMT2A (0.39) | KMT2AMAPTSSTR4HDAC3TNKS | |
| SCHEMBL11475593 | 0.92 | KMT2A (0.44) | KMT2AMAPTSSTR4HTTKCNN4 | |
| Maleic Acid SCHEMBL10360499 | 0.89 | HRH1 (0.44) | KMT2ALMNACYP2D6ADRB2CHRM2 | |
| Fumaric Acid SCHEMBL10555317 | 0.85 | HRH1 (0.50) | KMT2ALMNACYP2D6ADRB2CHRM2 | |
| Fumaric Acid SCHEMBL10550604 | 0.84 | HRH1 (0.49) | KMT2ALMNACYP2D6ADRB2CHRM2 | |
| SCHEMBL953947 | 0.80 | KMT2A (0.50) | KMT2AMAPTSSTR4KCNN4LMNA | |
| SCHEMBL4396455 | 0.80 | KMT2A (0.50) | KMT2AMAPTSSTR4KCNN4LMNA | |
| SCHEMBL958241 | 0.80 | KMT2A (0.50) | KMT2AMAPTSSTR4KCNN4LMNA | |
| Bromide SCHEMBL4505514 | 0.79 | KMT2A (0.49) | KMT2AMAPTSSTR4KCNN4LMNA | |
| Hydrochloric Acid SCHEMBL10869034 | 0.79 | KMT2A (0.49) | KMT2AMAPTSSTR4KCNN4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4133881-A | Azetidinyl acetonitrile and acetamide antiarrhythmia compositions and methods | A. H. ROBINS COMPANY, INCORPORATED (US) | 1979-01-09 | — | — | US | disclosed |