SCHEMBL11533924

SCHEMBL11533924

CN1CCCC(n2sc3ccccc3c2=O)C1

nearest known ligand 0.68

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CASP3 P42574 2/20 0.46
G6PD P11413 1/20 0.46
MPI P34949 1/20 0.46
KAT2B Q92831 2/20 0.43
HTR2B P41595 1/20 0.41
TMEM97 Q5BJF2 1/20 0.41
ADRA1A P35348 1/20 0.41
HRH1 P35367 1/20 0.41
ADRA1B P35368 1/20 0.41
HTR6 P50406 1/20 0.41
NPC1 O15118 1/20 0.39
GAA P10253 1/20 0.39
HPGD P15428 1/20 0.39
RAB9A P51151 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
ATM Q13315 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21033019 0.82 MPI (0.58) CASP3G6PDMPIHPGDRAB9A
SCHEMBL11452533 0.82 MPI (0.51) MPIHTR2BTMEM97ADRA1AHRH1
SCHEMBL8621565 0.81 MPI (0.57) CASP3G6PDMPINPC1GAA
SCHEMBL30434260 0.79 CASP3 (0.52) CASP3G6PDMPINPC1HPGD
SCHEMBL28457777 0.79 CASP3 (0.52) CASP3G6PDMPINPC1HPGD
SCHEMBL11531352 0.73 MPI (0.36) G6PDMPIKAT2BHTR2BTMEM97
SCHEMBL21033021 0.73 CASP3 (0.45) CASP3G6PDMPIHPGDRAB9A
SCHEMBL21033024 0.73 CASP3 (0.45) CASP3G6PDMPINPC1HPGD
SCHEMBL30122754 0.69 CASP3 (0.51) CASP3G6PDMPIKAT2BNPC1
SCHEMBL11532734 0.67 MPI (0.48) MPIHTR6SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4153702-A Basically alkylated dithiosalicyclic acid amides and their use as medicaments BAYER AKTIENGESELLSCHAFT (DE) 1979-05-08 US disclosed