Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPI | P34949 | 3/20 | 0.57 |
| ▸ | CASP3 | P42574 | 5/20 | 0.47 |
| ▸ | G6PD | P11413 | 2/20 | 0.47 |
| ▸ | PHOSPHO1 | Q8TCT1 | 3/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | PMM2 | O15305 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21033019 | 0.98 | MPI (0.58) | MPICASP3G6PDPHOSPHO1APOBEC3G | |
| SCHEMBL30434260 | 0.91 | CASP3 (0.52) | MPICASP3G6PDPHOSPHO1APOBEC3G | |
| SCHEMBL28457777 | 0.91 | CASP3 (0.52) | MPICASP3G6PDPHOSPHO1APOBEC3G | |
| SCHEMBL21033021 | 0.84 | CASP3 (0.45) | MPICASP3G6PDPHOSPHO1APOBEC3G | |
| SCHEMBL21033024 | 0.84 | CASP3 (0.45) | MPICASP3G6PDPHOSPHO1APOBEC3G | |
| SCHEMBL11533924 | 0.81 | CASP3 (0.46) | MPICASP3G6PDHPGDGAA | |
| SCHEMBL8625827 | 0.77 | HPGD (0.63) | HPGDKDM4EALDH1A1MAPTNPSR1 | |
| SCHEMBL787281 | 0.76 | MPI (0.64) | MPICDK4GAA | |
| SCHEMBL30122754 | 0.73 | CASP3 (0.51) | MPICASP3G6PDPHOSPHO1APOBEC3G | |
| SCHEMBL24766683 | 0.73 | CASP3 (0.55) | CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8277278-A | — | — | None | — | — | JP | disclosed |
| CN-111253335-B | New synthetic method of N-substituted benzisothiazolin-3-one derivative | 浙江扬帆新材料股份有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-111574472-B | Synthesis method of 1, 2-benzisothiazolin-3-ketone compound | 大连百傲化学股份有限公司 | 2022-03-08 | — | — | CN | disclosed |
| US-11053236-B2 | Substituted isoselenazolone anti-infective, anti-inflammatory, anti-cancer, cytoprotective, neuroprotective, and anti-oxidant agents | THE UNIVERSITY OF TOLEDO (US) | 2021-07-06 | — | — | US | disclosed |
| CN-111574472-A | Synthesis method of 1, 2-benzisothiazolin-3-ketone compound | 大连百傲化学股份有限公司 | 2020-08-25 | — | — | CN | disclosed |
| CN-111253335-A | Novel synthesis method of N-substituted benzisothiazolin-3-one derivative | 浙江扬帆新材料股份有限公司 | 2020-06-09 | — | — | CN | disclosed |
| WO-2019174279-A1 | 1,2-BENZISOSELENAZOL-3(2H)-ONE AND 1,2-BENZISOTHIAZOL-3(2H)-ONE DERIVATIVES AS BETA-LACTAM ANTIBIOTIC ADJUVANTS | THE HONG KONG POLYTECHNIC UNIVERSITY (CN) | 2019-09-19 | — | — | WO | disclosed |
| US-20190161482-A1 | SUBSTITUTED ISOSELENAZOLONE ANTI-INFECTIVE, ANTI-INFLAMMATORY, ANTI-CANCER, CYTOPROTECTIVE, NEUROPROTECTIVE, AND ANTI-OXIDANT AGENTS | THE UNIVERSITY OF TOLEDO (US) | 2019-05-30 | — | — | US | disclosed |
| US-5744609-A | REACTING AN ALKYLTHIOBENZAMIDE WITH A HALOGEN IN A HETEROGENOUS SOLVENT TO GIVE ALKYLSULFURYLBENZAMIDES INTERMEDIATES; USEFUL ANTIBACTERIAL AND ANTIFUNGAL AGENT | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1998-04-28 | — | — | US | disclosed |
| US-5672751-A | TREATMENT OF A HALOBENZAMIDE WITH AN ALKANETHIOL IN THE PRESENCE OF A PHASE TRANSFER CATALYST | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1997-09-30 | — | — | US | disclosed |
| EP-0657438-B1 | Method for producing 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS (JP) | 1997-07-30 | — | — | EP | disclosed |
| EP-0751123-A2 | Method for producing alkylsulfinylbenzamides | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1997-01-02 | — | — | EP | disclosed |
| JP-H08277278-A | PRODUCTION OF 1,2-BENZISOTHIAZOLES | SUMITOMO SEIKA CHEM CO LTD | 1996-10-22 | — | — | JP | disclosed |
| US-5508416-A | HALOGENATING A 2-(ALKYLTHIO)BENZAMIDE, CYCLIZATION TO HETERO RING AND N-S LINKAGE | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| EP-0657438-A2 | Method for producing alkylsulfinylbenzamides and 1,2-benzisothiazol-3-ones | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 1995-06-14 | — | — | EP | disclosed |
| EP-0018100-B1 | SUBSTITUTED AROMATIC BIOLOGICALLY ACTIVE COMPOUND, A PROCESS FOR ITS PREPARATION AND ITS USE AS BIOCIDE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-01-18 | — | — | EP | disclosed |
| EP-0018100-A2 | Substituted aromatic biologically active compound, a process for its preparation and its use as biocide | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-10-29 | — | — | EP | disclosed |
| US-4093730-A | Methods of using spermicidal vaginal compositions comprising 1,2-benzisothiazole derivatives | PREPHAR PROSPECTION DE RECHERCHES PHARMACEUTIQUES S.A. (CH) | 1978-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11053236-B2 | Substituted isoselenazolone anti-infective, anti-inflammatory, anti-cancer, cytoprotective, neuroprotective, and anti-oxidant agents | AIFM1, HSPE1, COX15 | MPI 1957/4885CASP3 10/4885G6PD 852/4885 |
| US-20190161482-A1 | SUBSTITUTED ISOSELENAZOLONE ANTI-INFECTIVE, ANTI-INFLAMMATORY, ANTI-CANCER, CYTOPROTECTIVE, NEUROPROTECTIVE, AND ANTI-OXIDANT AGENTS | AIFM1, HSPE1, COX15 | MPI 1957/4885CASP3 10/4885G6PD 852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.