Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 3/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11541817 | 0.90 | PNMT (0.39) | POLBIDO1PNMTTAAR1CYP2A13 | |
| Hydrochloric Acid SCHEMBL11534884 | 0.84 | SMN1; SMN2 (0.39) | POLBSMN1; SMN2LMNAHTTRAB9A | |
| Hydrochloric Acid SCHEMBL11536130 | 0.79 | POLB (0.38) | POLBIDO1PNMTSMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL11537265 | 0.78 | ALDH1A1 (0.40) | POLBRAB9AKMT2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL11540756 | 0.77 | CA1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL11536281 | 0.77 | NPSR1 (0.43) | SMN1; SMN2LMNAHTTRAB9AKMT2A | |
| Bromide SCHEMBL11536307 | 0.75 | LMNA (0.39) | POLBIDO1PNMTSMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL11540441 | 0.74 | POLB (0.34) | POLBIDO1PNMTLMNARAB9A | |
| Bromide SCHEMBL11533878 | 0.73 | CA1 (0.45) | SMN1; SMN2LMNAHTTRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL11537914 | 0.72 | KDM4E (0.35) | POLBSMN1; SMN2LMNAHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4163745-A | ANTIDIABETIC, HYPOGLYCEMIC | PFIZER INC. (US) | 1979-08-07 | — | — | US | disclosed |
| US-4141898-A | Imidazo pyridinium quaternary salts as hypoglycemic agents | PFIZER INC. (US) | 1979-02-27 | — | — | US | disclosed |
| US-4129567-A | IMIDAZOPYRIDINES AND ISOB IDINE | PFIZER INC. (US) | 1978-12-12 | — | — | US | disclosed |
| US-4093616-A | PYRROLO(1,2-A)PYRAZINIUM, PYRAZOLO(1,5-A)PYRIDINIUM, 1H-IMIDAZO(2,1-A)ISOQUINOLINIUM, OR IMIDAZO(5,1-A)ISOQUINOLINIUM SALTS | PFIZER INC. (US) | 1978-06-06 | — | — | US | disclosed |
| US-4044015-A | Imidazopyridinium compounds as hypoglycemic agents | PFIZER INC. (US) | 1977-08-23 | — | — | US | disclosed |