Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.36 |
| ▸ | GABRP | O00591 | 7/20 | 0.36 |
| ▸ | GABRD | O14764 | 7/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.36 |
| ▸ | GABRE | P78334 | 7/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 7/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 7/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 7/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11534109 | 0.90 | ALDH1A1 (0.38) | ALDH1A1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11542791 | 0.87 | MEN1 (0.39) | ALDH1A1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11533443 | 0.87 | KCNN4 (0.36) | ALDH1A1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11538842 | 0.87 | KMT2A (0.45) | ALDH1A1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11536777 | 0.87 | ALDH1A1 (0.39) | ALDH1A1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11538505 | 0.85 | GABRA1 (0.40) | ALDH1A1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11537930 | 0.85 | ALDH1A1 (0.38) | ALDH1A1GABRA2GABRB2MAPTKDM4E | |
| SCHEMBL11541337 | 0.84 | MAPK1 (0.43) | ALDH1A1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11534104 | 0.84 | MAPT (0.36) | ALDH1A1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11536196 | 0.84 | ALDH1A1 (0.39) | ALDH1A1GABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4139625-A | 5-(Substituted triphenylmethyl)picolinamides and their use as anti-acne agents | SCHERING CORPORATION (US) | 1979-02-13 | — | — | US | disclosed |
| US-4133887-A | Trityl picolinic acid derivatives and their use as anti-acne agents | SCHERING CORPORATION (US) | 1979-01-09 | — | — | US | disclosed |
| US-4127662-A | ANTIACNE | SCHERING CORPORATION (US) | 1978-11-28 | — | — | US | disclosed |
| US-4123433-A | ANTIACNE AGENTS | SCHERING CORPORATION (US) | 1978-10-31 | — | — | US | disclosed |
| US-4044140-A | Trityl picolinic acid derivatives and their use as anti-acne agents | SCHERING CORPORATION (US) | 1977-08-23 | — | — | US | disclosed |