Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11534252 | 0.89 | NPC1 (0.48) | NPC1MAPTRAB9AALOX15MAPK1 | |
| SCHEMBL11532310 | 0.89 | MAPT (0.48) | NPC1MAPTRAB9AALOX15MAPK1 | |
| SCHEMBL11535872 | 0.78 | NPC1 (0.53) | NPC1MAPTRAB9AALOX15MAPK1 | |
| SCHEMBL11535994 | 0.78 | MAPT (0.53) | NPC1MAPTRAB9AALOX15MAPK1 | |
| SCHEMBL11530620 | 0.78 | MAPT (0.44) | NPC1MAPTRAB9AALOX15MAPK1 | |
| SCHEMBL11532255 | 0.73 | ALDH1A1 (0.48) | NPC1RAB9AALOX15SMN1; SMN2ALDH1A1 | |
| SCHEMBL11537169 | 0.73 | PIM1 (0.40) | MAPTRAB9ASMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL11536698 | 0.70 | ALDH1A1 (0.46) | MAPTRAB9ANPSR1LMNAALDH1A1 | |
| SCHEMBL11176859 | 0.68 | MAPT (0.39) | NPC1MAPTRAB9AALOX15SMN1; SMN2 | |
| SCHEMBL11741038 | 0.68 | DAO (0.46) | NPC1MAPTLMNAHSD17B10GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4085117-A | DIURETIC-SALURETIC, URICOSURIC, HYPOTENSIVE, ANTIKALURETIC AGENTS | MERCK & CO., INC. (US) | 1978-04-18 | — | — | US | claimed |
| US-4154742-A | DIURETICS | MERCK & CO., INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4085117-A | DIURETIC-SALURETIC, URICOSURIC, HYPOTENSIVE, ANTIKALURETIC AGENTS | MERCK & CO., INC. (US) | 1978-04-18 | — | — | US | disclosed |