Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11532310 | 0.81 | MAPT (0.48) | ALDH1A1KMT2AMEN1POLBTDP1 | |
| SCHEMBL11537169 | 0.79 | PIM1 (0.40) | POLBTDP1KDM4ELMNAMAPT | |
| SCHEMBL11530908 | 0.78 | PIM1 (0.34) | POLBKDM4ELMNAMAPTGAA | |
| SCHEMBL11532255 | 0.77 | ALDH1A1 (0.48) | ALDH1A1KMT2AMEN1POLBTDP1 | |
| SCHEMBL11535390 | 0.75 | DAO (0.41) | POLBPIM1CES2CES1USP2 | |
| SCHEMBL11532265 | 0.73 | RAB9A (0.50) | ALDH1A1KMT2AMEN1POLBKDM4E | |
| SCHEMBL11166639 | 0.70 | PIM1 (0.32) | POLBPIM1USP2 | |
| SCHEMBL11535276 | 0.70 | NPC1 (0.45) | ALDH1A1KMT2AMEN1POLBTDP1 | |
| SCHEMBL10852840 | 0.68 | PIM1 (0.37) | POLBAPEX1PIM1USP2 | |
| SCHEMBL10862875 | 0.68 | PIM1 (0.40) | ALDH1A1KMT2AMEN1POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154742-A | DIURETICS | MERCK & CO., INC. (US) | 1979-05-15 | — | — | US | claimed |
| US-4154742-A | DIURETICS | MERCK & CO., INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4085117-A | DIURETIC-SALURETIC, URICOSURIC, HYPOTENSIVE, ANTIKALURETIC AGENTS | MERCK & CO., INC. (US) | 1978-04-18 | — | — | US | disclosed |