SCHEMBL11535575

SCHEMBL11535575

c1ccc2c(c1)N=C(N1CCNCC1)c1cscc1N2

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 11/20 0.60
CHRM1 P11229 10/20 0.60
CHRM2 P08172 6/20 0.60
CHRM4 P08173 6/20 0.60
CHRM5 P08912 6/20 0.60
CHRM3 P20309 6/20 0.60
DRD1 P21728 6/20 0.60
KCNH2 Q12809 5/20 0.60
ADRA1D P25100 5/20 0.60
HTR2A P28223 5/20 0.60
HTR2C P28335 5/20 0.60
ADRA1A P35348 5/20 0.60
HRH1 P35367 5/20 0.60
HTR2B P41595 5/20 0.60
ADRA2A P08913 4/20 0.60
ADRA2B P18089 4/20 0.60
ADRA2C P18825 4/20 0.60
ADRA1B P35368 4/20 0.60
CYP1A2 P05177 2/20 0.56
CYP3A4 P08684 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11635201 0.88 DRD2 (0.54) DRD2CHRM1CHRM2CHRM4CHRM5
SCHEMBL11531378 0.86 DRD2 (0.74) DRD2CHRM1CHRM2CHRM4CHRM5
SCHEMBL11631861 0.86 DRD2 (0.55) DRD2CHRM1CHRM2CHRM4CHRM5
SCHEMBL3410493 0.85 CHRM1 (0.74) DRD2CHRM1CHRM2CHRM4CHRM5
SCHEMBL11529615 0.83 CHRM1 (0.57) DRD2CHRM1CHRM2CHRM4CHRM5
SCHEMBL11528346 0.83 DRD2 (0.71) DRD2CHRM1CHRM2CHRM4CHRM5
SCHEMBL11629466 0.83 DRD2 (0.55) DRD2CHRM1CHRM2CHRM4CHRM5
SCHEMBL11620707 0.83 DRD2 (0.51) DRD2CHRM1CHRM2CHRM4CHRM5
SCHEMBL11635638 0.81 HRH4 (0.62) DRD2CHRM1CHRM2CHRM4CHRM5
SCHEMBL11536095 0.81 MEN1 (0.55) DRD2CHRM1CHRM2CHRM4CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4172831-A CENTRAL NERVOUS SYSTEM LILLY INDUSTRIES LIMITED (GB) 1979-10-30 US disclosed
US-4115568-A CNS ACTIVITY LILLY INDUSTRIES LIMITED (GB) 1978-09-19 US disclosed
US-4115574-A CNS ACTIVITY LILLY INDUSTRIES LIMITED (GB) 1978-09-19 US disclosed
US-4087421-A NEUROLEPTIC, ANTI-DEPRESSANT AND ANALGESTIC ACTIVITY AMERICAN CYANAMID COMPANY (US) 1978-05-02 US disclosed
US-3951981-A NEUROLEPTIC, ANALGESIC AMERICAN CYANAMID COMPANY (US) 1976-04-20 US disclosed