SCHEMBL11528346

SCHEMBL11528346

Clc1ccc2c(c1)N=C(N1CCNCC1)c1cscc1N2

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 10/20 0.71
DRD1 P21728 7/20 0.71
CHRM1 P11229 6/20 0.71
CHRM2 P08172 4/20 0.71
CHRM4 P08173 4/20 0.71
CHRM5 P08912 4/20 0.71
CHRM3 P20309 4/20 0.71
KCNH2 Q12809 4/20 0.71
CYP1A2 P05177 3/20 0.71
CYP3A4 P08684 3/20 0.71
CYP2D6 P10635 3/20 0.71
MTOR P42345 2/20 0.71
ADRA2A P08913 4/20 0.54
HTR2A P28223 4/20 0.54
DRD4 P21917 4/20 0.54
DRD3 P35462 4/20 0.54
HTR1A P08908 3/20 0.54
HRH4 Q9H3N8 3/20 0.54
ADRA2B P18089 3/20 0.54
ADRA2C P18825 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11533730 0.87 CHRM1 (0.71) DRD2DRD1CHRM1CHRM2CHRM4
SCHEMBL3411298 0.86 DRD2 (0.83) DRD2DRD1CHRM1CHRM2CHRM4
SCHEMBL11529615 0.86 CHRM1 (0.57) DRD2DRD1CHRM1CHRM2CHRM4
SCHEMBL11530516 0.85 DRD2 (0.51) DRD2DRD1CHRM1CHRM2CHRM4
SCHEMBL3407780 0.85 DRD2 (0.81) DRD2DRD1CHRM1CHRM2CHRM4
SCHEMBL11631525 0.83 HRH4 (0.74) DRD2DRD1CHRM1CHRM2CHRM4
N-Desmethylclozapine SCHEMBL29360816 0.83 DRD2 (1.00) DRD2DRD1CHRM1CHRM2CHRM4
N-Desmethylclozapine SCHEMBL781423 0.83 DRD2 (1.00) DRD2DRD1CHRM1CHRM2CHRM4
N-Desmethylclozapine SCHEMBL30416482 0.83 DRD2 (1.00) DRD2DRD1CHRM1CHRM2CHRM4
N-Desmethylclozapine SCHEMBL29365906 0.83 DRD2 (1.00) DRD2DRD1CHRM1CHRM2CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4172831-A CENTRAL NERVOUS SYSTEM LILLY INDUSTRIES LIMITED (GB) 1979-10-30 US disclosed
US-4115574-A CNS ACTIVITY LILLY INDUSTRIES LIMITED (GB) 1978-09-19 US disclosed
US-4115568-A CNS ACTIVITY LILLY INDUSTRIES LIMITED (GB) 1978-09-19 US disclosed
US-4087421-A NEUROLEPTIC, ANTI-DEPRESSANT AND ANALGESTIC ACTIVITY AMERICAN CYANAMID COMPANY (US) 1978-05-02 US disclosed