SCHEMBL11536342

SCHEMBL11536342

COc1c2occc2cc2cc(C(=O)O)c(=O)oc12

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 3/20 0.66
MAOB P27338 1/20 0.66
CYP1A2 P05177 1/20 0.60
CYP3A4 P08684 1/20 0.60
CYP2D6 P10635 1/20 0.60
CYP2A6 P11509 1/20 0.60
TSHR P16473 1/20 0.60
ACHE P22303 1/20 0.60
PDE4A P27815 1/20 0.60
MAPK1 P28482 1/20 0.60
CYP2C19 P33261 1/20 0.60
SLC6A3 Q01959 1/20 0.60
CYP2A13 Q16696 1/20 0.60
GPR35 Q9HC97 11/20 0.57
CA12 O43570 2/20 0.56
CA1 P00915 2/20 0.56
CA2 P00918 2/20 0.56
CA3 P07451 2/20 0.56
CA6 P23280 2/20 0.56
CA5A P35218 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9187739 0.83 GPR35 (0.79) MAOAMAOBTSHRGPR35CA12
SCHEMBL7066529 0.81 GPR35 (0.77) MAOAMAOBTSHRGPR35CA12
SCHEMBL7062287 0.80 GPR35 (0.56) MAOAMAOBTSHRGPR35CA12
SCHEMBL982766 0.80 CA12 (0.68) MAOAGPR35CA12CA1CA2
SCHEMBL9319388 0.77 GPR35 (0.82) GPR35CA12CA1CA2CA3
SCHEMBL10586869 0.76 MAOA (0.66) MAOAMAOBCYP1A2CYP3A4CYP2D6
Methoxsalen SCHEMBL2302069 0.76 CYP3A4 (1.00) MAOAMAOBCYP1A2CYP3A4CYP2D6
Methoxsalen SCHEMBL29376525 0.76 CYP3A4 (1.00) MAOAMAOBCYP1A2CYP3A4CYP2D6
Methoxsalen SCHEMBL19168 0.76 CYP3A4 (1.00) MAOAMAOBCYP1A2CYP3A4CYP2D6
SCHEMBL9387172 0.75 MAOA (0.64) MAOAMAOBCYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4150042-A 6-Hydroxy-7-methoxy-5-benzofuran carboxaldehyde and 2,3-dihydro-7-methoxy-6-benzofuranol HOFFMANN-LA ROCHE INC. (US) 1979-04-17 US disclosed
US-4147703-A Process to produce 8-methoxypsoralen HOFFMANN-LA ROCHE INC. (US) 1979-04-03 US disclosed
US-4107182-A 7-Oxo-9-methoxy-7H-furo[3,2-g][1]benzopyran-6-carboxylic acid HOFFMANN-LA ROCHE INC. (US) 1978-08-15 US disclosed
US-4107182-A 7-Oxo-9-methoxy-7H-furo[3,2-g][1]benzopyran-6-carboxylic acid HOFFMANN-LA ROCHE INC. (US) 1978-08-15 US disclosed