Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11554435 | 0.96 | DGAT1 (0.39) | CHEK1DGAT1KCNN4CYP19A1EGLN2 | |
| SCHEMBL11536025 | 0.88 | CHEK1 (0.41) | CHEK1DGAT1KCNN4ADORA2BADORA1 | |
| SCHEMBL11533562 | 0.87 | CHEK1 (0.43) | CHEK1DGAT1KIF11KDM4ENPSR1 | |
| SCHEMBL11536728 | 0.83 | CHEK1 (0.35) | CHEK1DGAT1KIF11EGLN2CTSS | |
| SCHEMBL11535669 | 0.82 | ALDH1A1 (0.44) | CHEK1DGAT1CYP19A1KIF11CTSS | |
| SCHEMBL11537287 | 0.81 | CTSS (0.48) | DGAT1KDM4ECTSS | |
| SCHEMBL11536344 | 0.81 | KIF11 (0.38) | CHEK1DGAT1KIF11KDM4EMEN1 | |
| SCHEMBL11534250 | 0.81 | CHEK1 (0.49) | CHEK1DGAT1ADORA1ADORA2AKIF11 | |
| SCHEMBL11537554 | 0.80 | KCNN4 (0.40) | KCNN4CYP19A1KIF11KDM4EHPGD | |
| SCHEMBL11537781 | 0.80 | CHEK1 (0.38) | CHEK1DGAT1CYP19A1KIF11KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4139625-A | 5-(Substituted triphenylmethyl)picolinamides and their use as anti-acne agents | SCHERING CORPORATION (US) | 1979-02-13 | — | — | US | disclosed |
| US-4133887-A | Trityl picolinic acid derivatives and their use as anti-acne agents | SCHERING CORPORATION (US) | 1979-01-09 | — | — | US | disclosed |
| US-4127662-A | ANTIACNE | SCHERING CORPORATION (US) | 1978-11-28 | — | — | US | disclosed |
| US-4044140-A | Trityl picolinic acid derivatives and their use as anti-acne agents | SCHERING CORPORATION (US) | 1977-08-23 | — | — | US | disclosed |