SCHEMBL11536738

SCHEMBL11536738

O=C1C2=C(CCCC2)C(=O)N1c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
GABRA1 P14867 1/20 0.44
GABRG2 P18507 1/20 0.44
GABRB3 P28472 1/20 0.44
GABRA3 P34903 1/20 0.44
MEN1 O00255 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
MAPT P10636 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
KMT2A Q03164 1/20 0.44
EPHX2 P34913 2/20 0.40
LIPE Q05469 2/20 0.39
CHRM5 P08912 1/20 0.39
HCRTR1 O43613 2/20 0.38
HCRTR2 O43614 2/20 0.38
ALDH1A1 P00352 1/20 0.38
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24997232 0.80 POLB (0.59) POLBL3MBTL1GABRA1GABRG2GABRB3
SCHEMBL10505868 0.78 POLB (0.62) POLBMEN1MAPTKMT2AALDH1A1
SCHEMBL30758589 0.77 KMT2A (0.57) POLBL3MBTL1MEN1MAPTKMT2A
SCHEMBL29168850 0.77 KMT2A (0.57) POLBL3MBTL1MEN1MAPTKMT2A
SCHEMBL11532005 0.74 IGF1R (0.39) HCRTR1HCRTR2ALDH1A1
SCHEMBL3006629 0.74 MGLL (0.58) POLBL3MBTL1MEN1CYP1A2CYP2D6
SCHEMBL28745022 0.73 MEN1 (0.49) POLBL3MBTL1GABRA1GABRG2GABRB3
SCHEMBL21383412 0.73 L3MBTL1 (0.54) POLBL3MBTL1GABRA1GABRG2GABRB3
SCHEMBL11667821 0.72 HCAR1 (0.42) MEN1MAPTKMT2AHCRTR1HCRTR2
SCHEMBL9966741 0.72 POLB (0.47) POLBL3MBTL1MEN1CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4157256-A Tetrahydrophthalimide and herbicide containing the same NIHON NOHYAKU CO. LTD. (JP) 1979-06-05 US claimed
JP-53095961-A None JP disclosed
US-4157256-A Tetrahydrophthalimide and herbicide containing the same NIHON NOHYAKU CO. LTD. (JP) 1979-06-05 US disclosed
US-4157256-A Tetrahydrophthalimide and herbicide containing the same NIHON NOHYAKU CO. LTD. (JP) 1979-06-05 US disclosed
JP-S5395961-A TETRAHYDROPHTHALIMIDE DERIVATIVES PROCESS FOR THEIR PREPARATION AND HERBICIDES CONTAINING THE SAME NIPPON NOHYAKU CO LTD 1978-08-22 JP disclosed