SCHEMBL11537181

SCHEMBL11537181

Cc1cccc(N(C)c2ccc(N)c3c2C(=O)c2ccccc2C3=O)c1C

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 5/20 0.51
CSNK1A1 P48729 2/20 0.51
CSNK1D P48730 2/20 0.51
CSNK1G1 Q9HCP0 2/20 0.51
MAOA P21397 2/20 0.51
FGR P09769 1/20 0.51
PIM1 P11309 1/20 0.51
DYRK1A Q13627 1/20 0.51
HIPK2 Q9H2X6 1/20 0.51
ALDH1A1 P00352 6/20 0.44
MEN1 O00255 5/20 0.44
KMT2A Q03164 5/20 0.44
MAPT P10636 4/20 0.44
MAPK1 P28482 4/20 0.44
SMN1; SMN2 Q16637 4/20 0.44
POLB P06746 3/20 0.44
RAB9A P51151 3/20 0.44
NPSR1 Q6W5P4 2/20 0.44
THRB P10828 2/20 0.44
FGB P02675 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11536538 0.90 ADORA2A (0.56) ADORA2ACSNK1A1CSNK1DCSNK1G1MAOA
SCHEMBL7601575 0.84 ALDH1A1 (0.63) ADORA2AMAOAALDH1A1MEN1KMT2A
SCHEMBL11800770 0.81 ALDH1A1 (0.51) ADORA2ACSNK1A1CSNK1DCSNK1G1MAOA
SCHEMBL28879261 0.78 MAPT (0.51) ADORA2AALDH1A1MEN1KMT2AMAPT
SCHEMBL6273633 0.74 ADORA2A (0.79) ADORA2ACSNK1A1CSNK1DCSNK1G1MAOA
SCHEMBL9844713 0.72 ALDH1A1 (0.79) ADORA2AMAOAALDH1A1MEN1KMT2A
SCHEMBL525762 0.72 ADORA2A (1.00) ADORA2ACSNK1A1CSNK1DCSNK1G1MAOA
SCHEMBL29361319 0.72 ADORA2A (1.00) ADORA2ACSNK1A1CSNK1DCSNK1G1MAOA
SCHEMBL5436537 0.72 TRPA1 (0.44) ALDH1A1MEN1KMT2AMAPTMAPK1
SCHEMBL11536543 0.71 P2RY4 (0.60) ADORA2ACSNK1A1CSNK1DCSNK1G1MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4176113-A ANTRAQUINONE DYES CIBA-GEIGY CORPORATION (US) 1979-11-27 US disclosed