Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11745480 | 0.75 | CHEK1 (0.60) | HSD17B10TNKS2PARP2MAPTTP53 | |
| SCHEMBL4613952 | 0.67 | TP53 (0.50) | HSD17B10MAPTTP53KMT2ATSHR | |
| SCHEMBL11222994 | 0.67 | HSD17B10 (0.48) | HSD17B10PDE11AMAPTTP53TSHR | |
| SCHEMBL11747298 | 0.66 | CHEK1 (0.55) | HSD17B10MAPTTP53KMT2ATSHR | |
| SCHEMBL11745014 | 0.66 | TNKS2 (0.72) | HSD17B10PDE11APARP15PARP10TNKS2 | |
| SCHEMBL4614943 | 0.64 | MAPT (0.49) | HSD17B10MAPTTP53KMT2ATSHR | |
| SCHEMBL4614949 | 0.64 | MAPT (0.49) | HSD17B10MAPTTP53KMT2ATSHR | |
| SCHEMBL8244059 | 0.62 | NPC1 (0.58) | HSD17B10MAPTTP53KMT2ATSHR | |
| SCHEMBL11746654 | 0.61 | CHEK1 (0.53) | HSD17B10TNKS2PARP2MAPTTP53 | |
| SCHEMBL24045600 | 0.60 | MAPK14 (0.46) | HSD17B10MAPTTP53KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4134914-A | 1-Acyl-4-substituted phenyl thiosemicarbazides | ELI LILLY AND COMPANY (US) | 1979-01-16 | — | — | US | disclosed |
| US-4082762-A | 4-(2-HALOPHENYL)-1,2,4-TRIAZOLE-3-THIOL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1978-04-04 | — | — | US | disclosed |
| US-3937713-A | Process for the preparation of s-triazolo[3,4-b]benzothiazoles | ELI LILLY AND COMPANY (US) | 1976-02-10 | — | — | US | disclosed |