Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 5/20 | 0.34 |
| ▸ | CA2 | P00918 | 5/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10870064 | 0.79 | ALDH1A1 (0.38) | CA1CA2MMP2MMP1MMP9 | |
| SCHEMBL10536289 | 0.76 | ALDH1A1 (0.41) | MEN1KMT2AF2PRSS1PRSS2 | |
| SCHEMBL7525621 | 0.75 | CYP1A2 (0.44) | CA1CA2CA9ALDH1A1PTGES2 | |
| SCHEMBL10729804 | 0.75 | CA1 (0.55) | MEN1KMT2AF2PRSS1PRSS2 | |
| SCHEMBL8877154 | 0.75 | MEN1 (0.44) | MEN1KMT2AF2PRSS1PRSS2 | |
| SCHEMBL3069664 | 0.75 | GAA (0.52) | MEN1KMT2AF2PRSS1PRSS2 | |
| SCHEMBL10667500 | 0.75 | MEN1 (0.44) | MEN1KMT2AF2PRSS1PRSS2 | |
| SCHEMBL10474078 | 0.75 | PTGES (0.55) | MEN1KMT2APTGESCA1CA2 | |
| Acrylamide SCHEMBL10414071 | 0.75 | TDP1 (0.38) | F2PRSS1PRSS2PRSS3SLC9A1 | |
| SCHEMBL8880393 | 0.74 | CA1 (0.45) | MEN1KMT2ACA1CA2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4136180-A | HYPOLIPIDEMIC SUBSTITUTED STYRENESULFONYLUREAS | PFIZER INC. (US) | 1979-01-23 | — | — | US | disclosed |
| US-4062960-A | Hypolipidemic alkenesulfonamides | PFIZER INC. (US) | 1977-12-13 | — | — | US | disclosed |
| US-3983107-A | ARTERIOSCLEROSIS | PFIZER INC. (US) | 1976-09-28 | — | — | US | disclosed |