Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | PMM2 | O15305 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11538165 | 0.89 | NPSR1 (0.51) | POLBHTTLMNAKDM4EMAPT | |
| SCHEMBL11540274 | 0.87 | NPSR1 (0.47) | HTTKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL11544638 | 0.86 | THRB (0.45) | POLBSMN1; SMN2HTTGAABRD4 | |
| SCHEMBL11575819 | 0.85 | HTT (0.40) | SMN1; SMN2HTTBRD4KDM4EMAPT | |
| SCHEMBL11538126 | 0.85 | MAPT (0.58) | POLBSMN1; SMN2HTTLMNAKDM4E | |
| SCHEMBL11543287 | 0.82 | HPGD (0.50) | SMN1; SMN2BRD4KDM4EMAPTALDH1A1 | |
| SCHEMBL11540070 | 0.80 | NPSR1 (0.46) | SMN1; SMN2HTTBRD4LMNAKDM4E | |
| SCHEMBL11541055 | 0.80 | NPSR1 (0.46) | POLBSMN1; SMN2HTTLMNAKDM4E | |
| SCHEMBL11540561 | 0.80 | TSHR (0.45) | SMN1; SMN2HTTGAAALDH1A1MEN1 | |
| SCHEMBL11542615 | 0.80 | NPSR1 (0.46) | HTTBRD4TP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4168312-A | Quinolone derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-09-18 | — | — | US | claimed |
| US-4168312-A | Quinolone derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1979-09-18 | — | — | US | disclosed |