Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 5/20 | 0.75 |
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.75 |
| ▸ | CFTR | P13569 | 1/20 | 0.50 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL11540575 | 1.00 | SLC6A3 (0.75) | SLC6A3SLC6A2SLC6A4CFTRGOPC | |
| SCHEMBL733008 | 0.87 | SLC6A3 (1.00) | SLC6A3SLC6A2SLC6A4CFTRGOPC | |
| Sulfuric Acid SCHEMBL16114544 | 0.87 | SRC (0.54) | SLC6A3SLC6A2SLC6A4CFTRGOPC | |
| Ammonia Solution, Strong SCHEMBL5999715 | 0.84 | SLC6A3 (0.95) | SLC6A3SLC6A2SLC6A4CFTRGOPC | |
| SCHEMBL1439868 | 0.82 | SLC6A3 (0.54) | SLC6A3SLC6A2SLC6A4KDM4EHSD17B10 | |
| SCHEMBL14393365 | 0.79 | SLC6A2 (0.75) | SLC6A3SLC6A2SLC6A4CFTRGOPC | |
| SCHEMBL29361168 | 0.76 | SLC6A2 (0.78) | SLC6A3SLC6A2SLC6A4CFTRGOPC | |
| Sulfuric Acid SCHEMBL6801606 | 0.76 | NOTUM (0.71) | KDM4EHSD17B10ALDH1A1KMT2AMEN1 | |
| SCHEMBL11535640 | 0.75 | CYP19A1 (0.83) | SLC6A3SLC6A2SLC6A4CFTRGOPC | |
| SCHEMBL10038666 | 0.75 | SLC6A2 (0.75) | SLC6A3SLC6A2SLC6A4CFTRGOPC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4138488-A | Diphenylmethyl picolinic acid derivatives and their use as anti-acne agents | SCHERING CORPORATION (US) | 1979-02-06 | — | — | US | disclosed |