Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11545937 | 0.86 | CAPN1 (0.52) | HPGDLMNATSHRHTTALDH1A1 | |
| SCHEMBL11542230 | 0.85 | ALDH1A1 (0.49) | HPGDLMNATSHRANO1ALDH1A1 | |
| SCHEMBL13669850 | 0.82 | MAPT (0.51) | TSHRHTTALDH1A1MEN1KMT2A | |
| SCHEMBL5230905 | 0.81 | HPGD (0.56) | HPGDMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL11543540 | 0.81 | ALDH1A1 (0.48) | LMNATSHRHTTANO1ALDH1A1 | |
| SCHEMBL28577924 | 0.80 | LMNA (0.56) | HPGDLMNATSHRHTTALDH1A1 | |
| SCHEMBL26200366 | 0.79 | MAPT (0.49) | HPGDTSHRHTTALDH1A1MEN1 | |
| SCHEMBL3065368 | 0.79 | KMT2A (0.49) | TSHRHTTALDH1A1MEN1KMT2A | |
| SCHEMBL11542176 | 0.79 | ALDH1A1 (0.46) | HPGDHTTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL11543797 | 0.77 | SLC6A2 (0.54) | TSHRHTTANO1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4175191-A | 4-Phenyl isoquinolines | SANDOZ, INC. (US) | 1979-11-20 | — | — | US | disclosed |
| US-3989704-A | 3-Substituted-4-aryl isoquinolines | SANDOZ, INC. (US) | 1976-11-02 | — | — | US | disclosed |