Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13669850 | 0.87 | MAPT (0.51) | L3MBTL1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3065368 | 0.84 | KMT2A (0.49) | L3MBTL1MAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL26200366 | 0.84 | MAPT (0.49) | HPGDL3MBTL1MAPTKMT2AMEN1 | |
| SCHEMBL8174111 | 0.83 | HPGD (0.53) | LMNAGAAHPGDL3MBTL1KMT2A | |
| SCHEMBL6748722 | 0.82 | MAPT (0.61) | LMNAGAAHPGDL3MBTL1MAPT | |
| SCHEMBL11545937 | 0.81 | CAPN1 (0.52) | LMNAGAAHPGDL3MBTL1MAPT | |
| SCHEMBL13670100 | 0.81 | KMT2A (0.50) | LMNAHPGDMAPTKMT2AMEN1 | |
| SCHEMBL11544239 | 0.80 | HPGD (0.50) | LMNAHPGDMAPTKMT2AMEN1 | |
| SCHEMBL6868432 | 0.79 | HPGD (0.66) | LMNAGAAHPGDL3MBTL1NPC1 | |
| SCHEMBL11542230 | 0.78 | ALDH1A1 (0.49) | LMNAHPGDMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113620893-B | Preparation method of letrozole | 杭州中美华东制药有限公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-113620893-A | Preparation method of letrozole | 杭州中美华东制药有限公司 | 2021-11-09 | — | — | CN | disclosed |
| CN-113072462-A | Preparation method of letrozole key intermediate | 杭州中美华东制药有限公司 | 2021-07-06 | — | — | CN | disclosed |