Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAAT3 | P53816 | 3/20 | 0.53 |
| ▸ | PLAAT5 | Q96KN8 | 3/20 | 0.53 |
| ▸ | PLAAT2 | Q9NWW9 | 3/20 | 0.53 |
| ▸ | PLAAT4 | Q9UL19 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9135914 | 0.91 | FFAR1 (0.50) | PLAAT3PLAAT5PLAAT2PLAAT4HDAC1 | |
| SCHEMBL4979314 | 0.89 | PLAAT3 (0.45) | PLAAT3PLAAT5PLAAT2PLAAT4HDAC1 | |
| SCHEMBL11572521 | 0.87 | HDAC3 (0.58) | PLAAT3PLAAT5PLAAT2PLAAT4HDAC1 | |
| SCHEMBL3249001 | 0.85 | HDAC3 (0.66) | PLAAT3PLAAT5PLAAT2PLAAT4HDAC1 | |
| SCHEMBL7328721 | 0.84 | PLAAT3 (0.55) | PLAAT3PLAAT5PLAAT2PLAAT4HDAC1 | |
| SCHEMBL10952971 | 0.84 | HDAC3 (0.64) | PLAAT3PLAAT5PLAAT2PLAAT4HDAC1 | |
| SCHEMBL9663077 | 0.84 | HDAC3 (0.64) | PLAAT3PLAAT5PLAAT2PLAAT4HDAC1 | |
| SCHEMBL27825386 | 0.82 | PLAAT3 (0.53) | PLAAT3PLAAT5PLAAT2PLAAT4HDAC1 | |
| SCHEMBL349314 | 0.82 | FFAR1 (0.71) | PLAAT3PLAAT5PLAAT2PLAAT4FFAR1 | |
| SCHEMBL2773933 | 0.82 | ESR1 (0.56) | HDAC2HDAC8MEN1KMT2ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 163 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704094-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2026-03-11 | — | — | EP | disclosed |
| US-12404265-B2 | Substituted pyridine derivatives as SARM1 inhibitors | NURA BIO, INC. (US) | 2025-09-02 | — | — | US | disclosed |
| US-20250122188-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2025-04-17 | — | — | US | disclosed |
| US-20240166652-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2024-05-23 | — | — | US | disclosed |
| US-11970481-B1 | Substituted pyridine derivatives as SARM1 inhibitors | NURA BIO, INC. (US) | 2024-04-30 | — | — | US | disclosed |
| EP-4356971-A2 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2024-04-24 | — | — | EP | disclosed |
| US-20240116901-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | NURA BIO, INC. | 2024-04-11 | — | — | US | disclosed |
| WO-2024050825-A1 | COMPOUNDS AS MLKL INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2024-03-14 | — | — | WO | disclosed |
| CN-117126119-A | Preparation method of (benzo) thiazole amide-containing compound | 济宁医学院 | 2023-11-28 | — | — | CN | disclosed |
| US-20230339913-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | NURA BIO, INC. | 2023-10-26 | — | — | US | disclosed |
| EP-0273451-B1 | LIPOXYGENASE INHIBITORY COMPOUNDS | Bristol-Myers Squibb Company (US) | 1992-04-01 | — | — | EP | disclosed |
| US-5001136-A | Leukotriene-synthesis-inhibiting 2-substitutedmethylamino-5-(hydroxy or alkoxy)pyridines | PFIZER INC. (US) | 1991-03-19 | — | — | US | disclosed |
| US-4861798-A | Lipoxygenase inhibitory compounds | BRISTOL-MYERS COMPANY (US) | 1989-08-29 | — | — | US | disclosed |
| EP-0273451-A2 | Lipoxygenase inhibitory compounds | Bristol-Myers Squibb Company (US) | 1988-07-06 | — | — | EP | disclosed |
| EP-0085321-B1 | DIPHOSPHONIC ACID DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-08-27 | — | — | EP | disclosed |
| US-4473560-A | Diphosphonic acid derivatives and pharmaceutical preparations containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-09-25 | — | — | US | disclosed |
| EP-0085321-A2 | Diphosphonic acid derivatives and pharmaceutical preparations containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-08-10 | — | — | EP | disclosed |
| US-4151303-A | Phenoxyalkylcarboxylic acid compounds and serum-lipid and triglyceride depressing therapeutic compositions | BOEHRINGER MANNHEIM GMBH (DE) | 1979-04-24 | — | — | US | disclosed |
| US-4006009-A | 1-Thiadiazolyl-6-acyloxytetrahydropyrimidinone herbicides | VELSICOL CHEMICAL CORPORATION (US) | 1977-02-01 | — | — | US | disclosed |
| US-4004912-A | 1-Thiadiazolyl-6-acyloxytetrahydropyrimidinone herbicides | VELSICOL CHEMICAL CORPORATION (US) | 1977-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12404265-B2 | Substituted pyridine derivatives as SARM1 inhibitors | SARM1, SARNP, ADRM1 | PLAAT3 1471/4885PLAAT5 1656/4885PLAAT2 1068/4885 |
| US-20250122188-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | PLAAT3 1077/4885PLAAT5 1504/4885PLAAT2 1246/4885 |
| US-11970481-B1 | Substituted pyridine derivatives as SARM1 inhibitors | SARM1, SARNP, ADRM1 | PLAAT3 1471/4885PLAAT5 1656/4885PLAAT2 1068/4885 |
| US-20230339913-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | SARM1, SARNP, ADRM1 | PLAAT3 1471/4885PLAAT5 1656/4885PLAAT2 1068/4885 |
| US-20240166652-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | PLAAT3 1077/4885PLAAT5 1504/4885PLAAT2 1246/4885 |
| US-20240116901-A1 | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS | SARM1, SARNP, ADRM1 | PLAAT3 1471/4885PLAAT5 1656/4885PLAAT2 1068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.