Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11545889 | 0.84 | LMNA (0.41) | MAPTALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL11545887 | 0.84 | LMNA (0.41) | MAPTALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL11547919 | 0.81 | CYP1A2 (0.47) | CYP1A2CYP2C9CYP2C19CYP3A4L3MBTL1 | |
| SCHEMBL11545108 | 0.75 | CCR2 (0.42) | CYP1A2CYP2C9CYP2C19CYP3A4L3MBTL1 | |
| SCHEMBL11544861 | 0.73 | MAPT (0.47) | CYP1A2CYP2C9CYP2C19CYP3A4L3MBTL1 | |
| SCHEMBL31383535 | 0.73 | KDM4E (0.38) | ALDH1A1HPGDKMT2AKDM4EMEN1 | |
| SCHEMBL11546013 | 0.72 | MCL1 (0.40) | MAPTALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL11547918 | 0.70 | CCR2 (0.53) | CYP1A2CYP2C9CYP2C19CYP3A4MAPT | |
| SCHEMBL11544397 | 0.70 | L3MBTL1 (0.44) | CYP1A2CYP2C9CYP2C19CYP3A4L3MBTL1 | |
| SCHEMBL28183120 | 0.69 | TSHR (0.43) | L3MBTL1KMT2AKDM4EMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4179513-A | Indole-2-carboxylic acids to effect CNS depressant activity | WARNER-LAMBERT COMPANY (US) | 1979-12-18 | — | — | US | disclosed |
| US-4117129-A | INDOLOBENZOXAZEPINES AS CNS DEPRESSANTS | WARNER-LAMBERT COMPANY (US) | 1978-09-26 | — | — | US | disclosed |
| US-4066660-A | INTERMEDIATES IN THE PREPARATION OF INDOLOBENZOXAZEPINES | WARNER-LAMBERT COMPANY (US) | 1978-01-03 | — | — | US | disclosed |
| US-4013641-A | INDOLOBENZOXAZEPINES | XEROX CORPORATION (US) | 1977-03-22 | — | — | US | disclosed |