Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | MARK3 | P27448 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | CAMK2B | Q13554 | 3/20 | 0.36 |
| ▸ | MARK2 | Q7KZI7 | 3/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.36 |
| ▸ | SRPK1 | Q96SB4 | 3/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.36 |
| ▸ | NEK4 | P51957 | 2/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.36 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.36 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.36 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.36 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11547197 | 0.82 | KMT2A (0.47) | MCL1MAPTKDM4ECRHBPCRHR2 | |
| SCHEMBL11548970 | 0.81 | L3MBTL1 (0.44) | MCL1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL11548971 | 0.81 | L3MBTL1 (0.44) | MCL1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL11545108 | 0.72 | CCR2 (0.42) | MCL1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL11544865 | 0.72 | CYP1A2 (0.40) | MCL1MAPTKDM4EALDH1A1GAA | |
| SCHEMBL11547200 | 0.72 | MCL1 (0.43) | MCL1MAPTKDM4ECRHBPCRHR2 | |
| SCHEMBL5799161 | 0.71 | EGFR (0.41) | MCL1MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL5407662 | 0.70 | KDM4E (0.59) | MAPTKDM4ECRHBPCRHR2ALDH1A1 | |
| SCHEMBL11546010 | 0.70 | ALDH1A1 (0.54) | MAPTKDM4ECRHBPCRHR2ALDH1A1 | |
| SCHEMBL11547919 | 0.69 | CYP1A2 (0.47) | MCL1MAPTKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4179513-A | Indole-2-carboxylic acids to effect CNS depressant activity | WARNER-LAMBERT COMPANY (US) | 1979-12-18 | — | — | US | disclosed |
| US-4117129-A | INDOLOBENZOXAZEPINES AS CNS DEPRESSANTS | WARNER-LAMBERT COMPANY (US) | 1978-09-26 | — | — | US | disclosed |
| US-4066660-A | INTERMEDIATES IN THE PREPARATION OF INDOLOBENZOXAZEPINES | WARNER-LAMBERT COMPANY (US) | 1978-01-03 | — | — | US | disclosed |
| US-4013641-A | INDOLOBENZOXAZEPINES | XEROX CORPORATION (US) | 1977-03-22 | — | — | US | disclosed |