Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11547028 | 0.91 | SIGMAR1 (0.55) | SIGMAR1CYP3A4CYP1A2CYP2D6TP53 | |
| Tiflorex SCHEMBL2108377 | 0.85 | SIGMAR1 (0.63) | SIGMAR1CYP3A4CYP1A2CYP2D6TP53 | |
| Tiflorex SCHEMBL11551709 | 0.84 | SIGMAR1 (0.62) | SIGMAR1CYP3A4CYP1A2CYP2D6TP53 | |
| SCHEMBL11545130 | 0.82 | SIGMAR1 (0.48) | SIGMAR1CYP3A4CYP1A2CYP2D6TP53 | |
| SCHEMBL11544879 | 0.80 | TAAR1 (0.50) | SIGMAR1CYP3A4CYP1A2CYP2D6TP53 | |
| SCHEMBL11544149 | 0.79 | SLC6A4 (0.46) | SIGMAR1CYP3A4CYP1A2CYP2D6TP53 | |
| SCHEMBL28403791 | 0.76 | SIGMAR1 (0.76) | SIGMAR1CYP3A4CYP1A2CYP2D6TP53 | |
| SCHEMBL17449716 | 0.76 | HTR2A (0.44) | SIGMAR1ADRA2CHTR2ASLC6A4ADRA1A | |
| SCHEMBL11547646 | 0.75 | HTR2A (0.58) | SIGMAR1HTR2ASLC6A4HTR2BSLC6A2 | |
| SCHEMBL11545202 | 0.75 | CETP (0.35) | SIGMAR1ADRA2CHTR2ASLC6A4ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4129598-A | ANOREXIGENIC AGENTS | SYNTHELABO (FR) | 1978-12-12 | — | — | US | claimed |
| US-4148923-A | 1-(3'-Trifluoromethylthiophenyl)-2-ethylaminopropane pharmaceutical composition and method for treating obesity | SYNTHELABO (FR) | 1979-04-10 | — | — | US | disclosed |
| US-4129598-A | ANOREXIGENIC AGENTS | SYNTHELABO (FR) | 1978-12-12 | — | — | US | disclosed |