Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | PNMT | P11086 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | CETP | P11597 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11546088 | 0.98 | HTR2A (0.57) | HTR2AHTR2CHTR2BPNMTSLC6A4 | |
| SCHEMBL17449716 | 0.88 | HTR2A (0.44) | HTR2AHTR2CHTR2BPNMTSLC6A4 | |
| SCHEMBL11544879 | 0.83 | TAAR1 (0.50) | HTR2AHTR2CHTR2BSLC6A4TAAR1 | |
| SCHEMBL935243 | 0.82 | EPHX1 (0.44) | HTR2AHTR2CHTR2BCETP | |
| SCHEMBL11544149 | 0.81 | SLC6A4 (0.46) | HTR2AHTR2CHTR2BSLC6A4TAAR1 | |
| Tiflorex SCHEMBL2108377 | 0.80 | SIGMAR1 (0.63) | HTR2AHTR2CHTR2BSLC6A4SLC6A2 | |
| SCHEMBL11545130 | 0.79 | SIGMAR1 (0.48) | HTR2AHTR2CHTR2BSLC6A4SLC6A2 | |
| Tiflorex SCHEMBL11551709 | 0.79 | SIGMAR1 (0.62) | HTR2AHTR2CHTR2BSLC6A4SLC6A2 | |
| SCHEMBL12300586 | 0.79 | CETP (0.41) | HTR2AHTR2CHTR2BSIGMAR1CYP2A6 | |
| SCHEMBL5729617 | 0.79 | PNMT (0.44) | HTR2CPNMTTAAR1CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4129598-A | ANOREXIGENIC AGENTS | SYNTHELABO (FR) | 1978-12-12 | — | — | US | claimed |
| US-4148923-A | 1-(3'-Trifluoromethylthiophenyl)-2-ethylaminopropane pharmaceutical composition and method for treating obesity | SYNTHELABO (FR) | 1979-04-10 | — | — | US | disclosed |
| US-4129598-A | ANOREXIGENIC AGENTS | SYNTHELABO (FR) | 1978-12-12 | — | — | US | disclosed |
| US-3965190-A | ANOREXIGENIC | SYNTHELABO (FR) | 1976-06-22 | — | — | US | disclosed |