Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 8/20 | 0.48 |
| ▸ | REN | P00797 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PEPD | P12955 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380820 | 0.83 | ACE (0.54) | ACERENKDM4EF2LMNA | |
| Water SCHEMBL5570208 | 0.82 | ACE (0.52) | ACERENKDM4EF2LMNA | |
| SCHEMBL11548591 | 0.80 | ALDH1A1 (0.57) | ACE | |
| SCHEMBL11545173 | 0.77 | ACE (0.50) | RAB9AACERENKDM4EF2 | |
| SCHEMBL5742535 | 0.76 | ACE (0.62) | RAB9AACERENKDM4EF2 | |
| SCHEMBL15854285 | 0.76 | ACE (0.62) | RAB9AACERENKDM4EF2 | |
| SCHEMBL5742529 | 0.76 | ACE (0.62) | RAB9AACERENKDM4EF2 | |
| SCHEMBL21246655 | 0.75 | ACE (0.60) | RAB9AACERENKDM4EF2 | |
| SCHEMBL21246658 | 0.75 | ACE (0.60) | RAB9AACERENKDM4EF2 | |
| SCHEMBL11546811 | 0.75 | ACE (0.58) | RAB9AACERENKDM4EF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154840-A | Antihypertensive pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |