Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | USP10 | Q14694 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL573292 | 0.88 | VCAM1 (0.47) | ALDH1A1MAPTPKMPOLBLMNA | |
| SCHEMBL573293 | 0.88 | VCAM1 (0.47) | ALDH1A1MAPTPKMPOLBLMNA | |
| SCHEMBL11542928 | 0.84 | HCAR3 (0.42) | KMT2AMEN1ALDH1A1MAPTPOLB | |
| SCHEMBL14879872 | 0.82 | THRB (0.54) | KMT2AMEN1THRBALDH1A1MAPT | |
| SCHEMBL11855920 | 0.81 | ALDH1A1 (0.50) | KMT2AMEN1THRBALDH1A1MAPT | |
| SCHEMBL11541849 | 0.79 | ALDH1A1 (0.56) | KMT2AMEN1ALDH1A1MAPTNPC1 | |
| SCHEMBL2655338 | 0.79 | KMT2A (0.57) | KMT2AMEN1THRBALDH1A1MAPT | |
| SCHEMBL10606064 | 0.75 | KMT2A (0.53) | KMT2AMEN1ALDH1A1MAPTNPC1 | |
| SCHEMBL21436496 | 0.74 | MAPT (0.50) | KMT2AMEN1ALDH1A1MAPTNPC1 | |
| SCHEMBL21436495 | 0.74 | MAPT (0.50) | KMT2AMEN1ALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4161531-A | Diuretic and saluretic 5-sulfamoylbenzoic acid derivatives carrying a heterocyclic substituent | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-17 | — | — | US | disclosed |
| US-4118397-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |
| US-4111953-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |
| US-4093735-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-06-06 | — | — | US | disclosed |
| US-4010273-A | DIURETICS, SALURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-03-01 | — | — | US | disclosed |