SCHEMBL11547366

SCHEMBL11547366

CC1C(=O)c2ccccc2C1c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.45
MAPK1 P28482 2/20 0.45
LMNA P02545 1/20 0.45
TP53 P04637 1/20 0.45
CYP3A4 P08684 1/20 0.45
MAPT P10636 1/20 0.45
HTR2B P41595 1/20 0.45
ALDH1A1 P00352 1/20 0.43
EDNRA P25101 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.37
CYP2D6 P10635 1/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
ACHE P22303 1/20 0.36
ATM Q13315 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
TOP1 P11387 1/20 0.35
CYP19A1 P11511 1/20 0.35
PARP3 Q9Y6F1 1/20 0.35
SLC6A3 Q01959 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14665269 0.85 MAPT (0.45) CYP1A2MAPK1LMNATP53CYP3A4
SCHEMBL8117184 0.82 CYP1A2 (0.50) CYP1A2MAPK1LMNATP53CYP3A4
SCHEMBL21197721 0.78 MAPK1 (0.41) CYP1A2MAPK1LMNACYP3A4ALDH1A1
SCHEMBL15624258 0.77 ACHE (0.42) CYP1A2MAPK1LMNATP53CYP3A4
SCHEMBL822181 0.77 ACHE (0.42) CYP1A2MAPK1LMNATP53CYP3A4
SCHEMBL11549835 0.77 S100A4 (0.54) CYP1A2MAPK1LMNATP53CYP3A4
SCHEMBL11545827 0.77 CYP1A2 (0.45) CYP1A2MAPK1LMNATP53CYP3A4
SCHEMBL11547901 0.77 EDNRA (0.43) CYP1A2MAPK1LMNATP53CYP3A4
SCHEMBL11544482 0.77 MEN1 (0.45) CYP1A2MAPK1LMNATP53CYP3A4
Hydrochloric Acid SCHEMBL11012570 0.76 LMNA (0.48) CYP1A2MAPK1LMNATP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111269075-B Efficient synthesis method of 2, 3-indanones 西北工业大学 2021-11-02 CN disclosed
CN-111269075-A Efficient synthesis method of 2, 3-indanones 西北工业大学 2020-06-12 CN disclosed
US-4151182-A CATALYTIC OXIDATION FROM INDANS OR DIPHENYLMETHANE DERIVATIVES BADISCHE ANILIN- & SODA-FABRIK AKTIENGESELLSCHAFT (DE) 1979-04-24 US disclosed