SCHEMBL11547427

SCHEMBL11547427

O=C(O)C(Cl)c1csc(Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
DAO P14920 3/20 0.48
TP53 P04637 1/20 0.33
HCAR3 P49019 1/20 0.33
HCAR2 Q8TDS4 1/20 0.33
SLC6A2 P23975 4/20 0.31
SLC6A3 Q01959 2/20 0.31
KEAP1 Q14145 1/20 0.30
NFE2L2 Q16236 1/20 0.30
ALAD P13716 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11000181 0.98 DAO (0.47) DAOTP53HCAR3HCAR2SLC6A2
SCHEMBL11080855 0.78 DAO (0.39) DAOTP53HCAR3HCAR2SLC6A2
SCHEMBL24917627 0.76 DAO (0.44) DAOTP53HCAR3HCAR2
SCHEMBL1559961 0.73
SCHEMBL2454097 0.66 CYP2C9 (0.47)
SCHEMBL4837077 0.65 TSHR (0.47)
SCHEMBL5325296 0.64 SRC (0.56)
SCHEMBL664900 0.64 SRC (0.56)
SCHEMBL10939067 0.64 MEN1 (0.53) KEAP1NFE2L2
SCHEMBL10441312 0.64 CES2 (0.45) SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0002846-A1 3-Thienylmalonic acids, the corresponding diesters and their preparation Océ-Andeno B.V. (NL) 1979-07-11 EP disclosed