Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | PDE1A | P54750 | 1/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2378105 | 0.84 | MAPK1 (0.47) | MAPTLMNATSHRMAPK1HTT | |
| SCHEMBL842358 | 0.81 | MAPK1 (0.49) | MAPTLMNATSHRMAPK1HTT | |
| SCHEMBL17714286 | 0.80 | LMNA (0.43) | MAPTLMNATSHRMAPK1HTT | |
| SCHEMBL13754029 | 0.80 | ALDH1A1 (0.49) | MAPTLMNATSHRMAPK1HTT | |
| SCHEMBL15008446 | 0.80 | CYP4F2 (0.49) | MAPTTSHRCYP1A2CYP2C9HPGD | |
| SCHEMBL29508729 | 0.80 | CYP1A2 (0.63) | MAPTLMNATSHRMAPK1HTT | |
| SCHEMBL879988 | 0.80 | CYP1A2 (0.63) | MAPTLMNATSHRMAPK1HTT | |
| SCHEMBL10348307 | 0.80 | LMNA (0.50) | MAPTLMNATSHRMAPK1HTT | |
| SCHEMBL19014549 | 0.80 | MEN1 (0.58) | MAPTLMNATSHRMAPK1CYP1A2 | |
| SCHEMBL28140053 | 0.80 | EPHX2 (0.49) | MAPTLMNATSHRMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4148923-A | 1-(3'-Trifluoromethylthiophenyl)-2-ethylaminopropane pharmaceutical composition and method for treating obesity | SYNTHELABO (FR) | 1979-04-10 | — | — | US | disclosed |
| US-4129598-A | ANOREXIGENIC AGENTS | SYNTHELABO (FR) | 1978-12-12 | — | — | US | disclosed |