SCHEMBL11547770

SCHEMBL11547770

CCCCOC(=O)/C=C/C(C)Oc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.42
CYP1A1 P04798 2/20 0.40
CYP1B1 Q16678 2/20 0.40
HCAR2 Q8TDS4 1/20 0.39
APP P05067 1/20 0.39
PPARG P37231 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
TSHR P16473 1/20 0.38
CYP2C19 P33261 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ALOX5 P09917 1/20 0.38
PSEN1 P49768 1/20 0.38
FPR2 P25090 1/20 0.37
SCN9A Q15858 1/20 0.37
PPARA Q07869 1/20 0.37
MAOB P27338 1/20 0.37
MMP14 P50281 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11549517 0.97 HCAR2 (0.40) ATMCYP1A1CYP1B1HCAR2APP
SCHEMBL11368437 0.97 HCAR2 (0.40) ATMCYP1A1CYP1B1HCAR2APP
SCHEMBL11547478 0.91 PPARA (0.37) CYP1A1CYP1B1PPARGFPR2SCN9A
SCHEMBL732546 0.90 ALDH1A1 (0.42) CYP1A1CYP1B1PPARGFPR2SCN9A
SCHEMBL732547 0.90 ALDH1A1 (0.42) CYP1A1CYP1B1PPARGFPR2SCN9A
SCHEMBL11283883 0.89 MMP14 (0.44) CYP1A1CYP1B1PPARGPPARAMAOB
SCHEMBL11281044 0.89 ALOX5 (0.37) CYP1A1CYP1B1PPARGALOX5FPR2
SCHEMBL11547195 0.89 SCN9A (0.37) CYP1A1CYP1B1PPARGFPR2SCN9A
SCHEMBL11554606 0.89 LMNA (0.46) CYP1A1CYP1B1PPARGFPR2SCN9A
SCHEMBL11550410 0.89 PPARG (0.37) CYP1A1CYP1B1PPARGFPR2SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4163661-A Phenoxyphenoxy crotonic acid derivatives and herbicidal composition KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1979-08-07 US disclosed