Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | TOP2A | P11388 | 2/20 | 0.50 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11576628 | 0.86 | MAPT (0.58) | KDM4EMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL11661097 | 0.83 | MAPT (0.55) | KDM4EMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL4936991 | 0.83 | TOP2A (0.58) | KDM4EMAPTALDH1A1HPGDTOP2A | |
| SCHEMBL29965486 | 0.83 | TOP2A (0.58) | KDM4EMAPTALDH1A1HPGDTOP2A | |
| SCHEMBL11549367 | 0.80 | TOP2A (0.50) | KDM4EMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL13343647 | 0.79 | PARP1 (0.50) | KDM4EMAPTALDH1A1HPGDTOP2A | |
| SCHEMBL8199577 | 0.79 | ALDH1A1 (0.57) | KDM4EMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL13343610 | 0.77 | TUBB4A (0.52) | KDM4ETOP2ATOP2BBRD4HSD17B10 | |
| SCHEMBL8197038 | 0.77 | PIN1 (0.67) | KDM4EALDH1A1TP53HSD17B10PIN1 | |
| SCHEMBL13343598 | 0.77 | KDM4E (0.57) | KDM4EMAPTALDH1A1HPGDHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4134981-A | ANTIALLERGENS | PFIZER INC. (US) | 1979-01-16 | — | — | US | disclosed |
| US-4120962-A | Fused pyrimidin-4(3H)-ones as antiallergy agents | PFIZER INC. (US) | 1978-10-17 | — | — | US | disclosed |
| US-4044134-A | FUSED WITH QUINOLINE OR PYRIDINE, 2-METHYL, ETHYL, OR ACETYL GROUP | PFIZER INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-3974161-A | Fused pyrimidin-4(3H)-ones as antiallergy agents | PFIZER INC. (US) | 1976-08-10 | — | — | US | disclosed |