Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11548610 | 0.96 | POLB (0.47) | POLBALDH1A1NPSR1MAPTCYP1A2 | |
| SCHEMBL11548958 | 0.88 | POLB (0.57) | POLBALDH1A1NPSR1MAPTCYP1A2 | |
| SCHEMBL11545374 | 0.83 | ALDH1A1 (0.53) | POLBALDH1A1NPSR1MAPTCYP1A2 | |
| SCHEMBL11545404 | 0.82 | ADRB3 (0.41) | ADRB3OPRM1OPRD1OPRK1MEN1 | |
| SCHEMBL11547011 | 0.81 | POLB (0.42) | POLBALDH1A1NPSR1MAPTCYP1A2 | |
| SCHEMBL11546850 | 0.80 | ALDH1A1 (0.52) | POLBALDH1A1NPSR1MAPTCYP1A2 | |
| SCHEMBL11546634 | 0.79 | POLB (0.44) | POLBALDH1A1NPSR1MAPTCYP1A2 | |
| SCHEMBL21759058 | 0.78 | POLB (0.59) | POLBALDH1A1NPSR1MAPTCYP1A2 | |
| SCHEMBL11549323 | 0.78 | KDM4E (0.49) | ALDH1A1NPSR1ABCB1ADRB3KMT2A | |
| SCHEMBL11546336 | 0.78 | ABCB1 (0.45) | POLBALDH1A1NPSR1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4139623-A | HYPOTENSIVE AGENTS | C-G CORP. (US) | 1979-02-13 | — | — | US | disclosed |
| US-4027027-A | BETA-RECEPTOR-BLOCKERS, HYPOTENSIVES AND VALODILATORS; FOR TREATING ARRYTHMIAS AND ANGINA PECTORIS | CIBA-GEIGY CORPORATION (US) | 1977-05-31 | — | — | US | disclosed |