Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NNMT | P40261 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11548610 | 0.92 | POLB (0.47) | POLBALDH1A1CYP1A2MAPTCYP2D6 | |
| SCHEMBL11545374 | 0.89 | ALDH1A1 (0.53) | POLBALDH1A1CYP1A2MAPTCYP2D6 | |
| SCHEMBL11549384 | 0.88 | POLB (0.47) | POLBALDH1A1CYP1A2MAPTCYP2D6 | |
| SCHEMBL11547011 | 0.86 | POLB (0.42) | POLBALDH1A1CYP1A2MAPTCYP2D6 | |
| SCHEMBL11546850 | 0.85 | ALDH1A1 (0.52) | POLBALDH1A1CYP1A2MAPTCYP2D6 | |
| SCHEMBL11546206 | 0.82 | OPRM1 (0.52) | NNMTOPRM1OPRD1OPRK1 | |
| SCHEMBL11549703 | 0.77 | ADRB2 (0.55) | MAPTKDM4ELMNAABCB1GAA | |
| Methyl Alcohol SCHEMBL11168835 | 0.77 | ALDH1A1 (0.53) | POLBALDH1A1CYP1A2MAPTCYP2D6 | |
| SCHEMBL13916263 | 0.76 | POLB (0.49) | POLBALDH1A1CYP1A2MAPTTSHR | |
| SCHEMBL11546634 | 0.75 | POLB (0.44) | POLBALDH1A1CYP1A2MAPTCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4139623-A | HYPOTENSIVE AGENTS | C-G CORP. (US) | 1979-02-13 | — | — | US | disclosed |
| US-4027027-A | BETA-RECEPTOR-BLOCKERS, HYPOTENSIVES AND VALODILATORS; FOR TREATING ARRYTHMIAS AND ANGINA PECTORIS | CIBA-GEIGY CORPORATION (US) | 1977-05-31 | — | — | US | disclosed |