Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11347005 | 0.87 | OPRM1 (0.47) | OPRM1SIGMAR1KDM4EMEN1NPC1 | |
| SCHEMBL11454750 | 0.86 | OPRM1 (0.53) | OPRM1SIGMAR1OPRD1OPRK1SLC22A1 | |
| SCHEMBL11546721 | 0.86 | ALDH1A1 (0.49) | OPRM1SIGMAR1KDM4EMEN1NPC1 | |
| SCHEMBL11550133 | 0.86 | ALDH1A1 (0.49) | OPRM1SIGMAR1KDM4EMEN1NPC1 | |
| SCHEMBL11348029 | 0.83 | OPRM1 (0.49) | OPRM1SIGMAR1OPRD1OPRK1SLC22A1 | |
| SCHEMBL11434729 | 0.81 | OPRM1 (0.50) | OPRM1SIGMAR1KDM4EMEN1NPC1 | |
| SCHEMBL11434731 | 0.81 | OPRM1 (0.50) | OPRM1SIGMAR1KDM4EMEN1NPC1 | |
| SCHEMBL11447557 | 0.81 | OPRM1 (0.50) | OPRM1SIGMAR1KDM4EMEN1NPC1 | |
| SCHEMBL11454751 | 0.80 | OPRD1 (0.43) | OPRM1SIGMAR1KDM4EMEN1NPC1 | |
| SCHEMBL11447019 | 0.80 | OPRM1 (0.49) | OPRM1SIGMAR1KDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4159339-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-06-26 | — | — | US | disclosed |
| US-4156014-A | N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of depression | THE UPJOHN COMPANY (US) | 1979-05-22 | — | — | US | disclosed |