Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 8/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11550650 | 0.92 | SLC22A12 (0.64) | SLC22A12CYP2C9EYA3CYP2C19GAA | |
| SCHEMBL11555915 | 0.91 | SLC22A12 (0.52) | SLC22A12EYA3CYP2C19ALDH1A1L3MBTL1 | |
| SCHEMBL11552784 | 0.88 | SLC22A12 (0.51) | SLC22A12CYP2C9EYA3CYP2C19MEN1 | |
| SCHEMBL11553196 | 0.87 | SLC22A12 (0.50) | SLC22A12CYP2C9EYA3CYP2C19MEN1 | |
| SCHEMBL11556111 | 0.84 | CYP2C19 (0.60) | SLC22A12CYP2C9EYA3CYP2C19MEN1 | |
| SCHEMBL1287600 | 0.81 | SLC22A12 (0.88) | SLC22A12CYP2C9EYA3CYP2C19GAA | |
| SCHEMBL11556805 | 0.79 | STAT3 (0.45) | SLC22A12CYP2C19LMNAALDH1A1MAPT | |
| SCHEMBL1287502 | 0.78 | SLC22A12 (1.00) | SLC22A12CYP2C9EYA3CYP2C19MEN1 | |
| SCHEMBL11553201 | 0.78 | CA2 (0.55) | GAAALDH1A1MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL940166 | 0.77 | MMP2 (0.60) | GAALMNAKMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4156732-A | Certain pharmaceutical sulfamoylbenzoyl benzofurans, benzothiophenes, and indoles | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-29 | — | — | US | disclosed |
| EP-0000128-A1 | Sulfamoylaryl ketones, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-01-10 | — | — | EP | disclosed |