Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolamolol SCHEMBL611643 | 0.85 | ATM (0.59) | CYP3A4CYP2D6ATMADRB2ADRB1 | |
| Tolamolol SCHEMBL613511 | 0.85 | ATM (0.59) | CYP3A4CYP2D6ATMADRB2ADRB1 | |
| SCHEMBL11541226 | 0.84 | ADRB2 (0.64) | CYP2D6ATMADRB2ADRB1ADRB3 | |
| SCHEMBL11542670 | 0.84 | CYP3A4 (0.72) | CYP3A4CYP2D6ATMADRB2ADRB1 | |
| Tolamolol SCHEMBL8057907 | 0.84 | ATM (0.58) | CYP3A4CYP2D6ATMADRB2ADRB1 | |
| SCHEMBL11543785 | 0.83 | ADRB2 (0.56) | CYP3A4CYP2D6ATMADRB2ADRB1 | |
| SCHEMBL11545485 | 0.79 | ADRB2 (0.51) | CYP3A4CYP2D6ATMADRB2ADRB1 | |
| SCHEMBL11543422 | 0.78 | ADRB1 (0.53) | CYP3A4CYP2D6ATMADRB2ADRB1 | |
| SCHEMBL11546599 | 0.78 | ADRB2 (0.47) | CYP3A4CYP2D6ADRB2ADRB1ADRB3 | |
| SCHEMBL11544543 | 0.78 | CYP3A4 (0.58) | CYP3A4CYP2D6ATMADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4165384-A | ADRENERGIC BLOCKING AGENTS, CARDIOVASCULAR DISORDERS | AKTIEBOLAGET HASSLE (SE) | 1979-08-21 | — | — | US | disclosed |