Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 6/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CASR | P41180 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GRK3 | P35626 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11543785 | 0.92 | ADRB2 (0.56) | ADRB2ADRB3ADRB1CYP1A2ATM | |
| Tolamolol SCHEMBL611643 | 0.83 | ATM (0.59) | ADRB2ADRB3ADRB1CYP1A2ATM | |
| Tolamolol SCHEMBL613511 | 0.83 | ATM (0.59) | ADRB2ADRB3ADRB1CYP1A2ATM | |
| Tolamolol SCHEMBL8057907 | 0.82 | ATM (0.58) | ADRB2ADRB3ADRB1CYP1A2ATM | |
| SCHEMBL11543752 | 0.82 | ATM (0.55) | ADRB2ADRB3ADRB1CYP1A2ATM | |
| SCHEMBL11545703 | 0.80 | ADRB1 (0.45) | ADRB2ADRB3ADRB1MEN1KMT2A | |
| SCHEMBL11547838 | 0.79 | ADRB1 (0.56) | ADRB2ADRB3ADRB1CYP1A2ATM | |
| SCHEMBL11549418 | 0.79 | ADRB2 (0.48) | ADRB2ADRB3ADRB1CYP1A2ATM | |
| SCHEMBL11550848 | 0.79 | CYP3A4 (0.54) | ADRB2ADRB3ADRB1CYP1A2ATM | |
| SCHEMBL11541226 | 0.79 | ADRB2 (0.64) | ADRB2ADRB3ADRB1CYP1A2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4165384-A | ADRENERGIC BLOCKING AGENTS, CARDIOVASCULAR DISORDERS | AKTIEBOLAGET HASSLE (SE) | 1979-08-21 | — | — | US | disclosed |