Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 7/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | ESR1 | P03372 | 3/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL11561438 | 0.93 | ADRB2 (0.48) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL11277418 | 0.84 | ADRB2 (0.53) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| Alcohol SCHEMBL11558491 | 0.84 | MAPT (0.39) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| Alcohol SCHEMBL11559195 | 0.83 | KMT2A (0.39) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| Alcohol SCHEMBL11277403 | 0.81 | KMT2A (0.43) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL11282470 | 0.81 | ADRB2 (0.38) | ADRB2ADRB1ADRB3MAPTTHRB | |
| Alcohol SCHEMBL11558977 | 0.80 | ESR1 (0.40) | KMT2AMEN1ESR1ESR2MAPT | |
| Alcohol SCHEMBL11558382 | 0.80 | CCR5 (0.39) | ADRB2KMT2AMEN1ESR1ESR2 | |
| SCHEMBL11279443 | 0.79 | ADRB2 (0.45) | ADRB2ADRB1ADRB3KMT2AMEN1 | |
| SCHEMBL11284114 | 0.78 | ACHE (0.38) | ADRB2ADRB1ADRB3KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4138581-A | BRONCHODILATOR AGENTS, ADRENERGIC STIMULANTS | STERLING DRUGS INC. (US) | 1979-02-06 | — | — | US | claimed |