Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | PDE6D | O43924 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11559265 | 0.87 | GLS (0.47) | GLSKDM4EALDH1A1BLMOPRD1 | |
| SCHEMBL27747651 | 0.74 | SLC6A4 (0.48) | SLC6A4SLC6A3 | |
| SCHEMBL27518018 | 0.72 | BLM (0.42) | GLSBLMOPRD1SLC6A2SLC6A4 | |
| SCHEMBL30184374 | 0.72 | LMNA (0.46) | GLSALDH1A1BLMOPRD1SMN1; SMN2 | |
| SCHEMBL9267633 | 0.71 | GLS (0.42) | GLSALDH1A1SLC6A4SLC6A3 | |
| SCHEMBL27747201 | 0.71 | SOS1 (0.41) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11556711 | 0.70 | GABRP (0.42) | ALDH1A1RECQLMEN1KMT2AATM | |
| SCHEMBL11564048 | 0.70 | GABRP (0.38) | GLSALDH1A1RECQLMEN1KMT2A | |
| SCHEMBL11564199 | 0.70 | PRKCA (0.40) | GLSALDH1A1SMN1; SMN2 | |
| SCHEMBL20594754 | 0.69 | BLM (0.45) | KDM4EBLMOPRD1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000167-A1 | 1,2,3,6-Tetrahydroisonicotinic acid and derivatives thereof, methods and starting products for their preparation, and pharmaceutical compositions containing them. | Krogsgaard-Larsen, Povl (DK) | 1979-01-10 | — | — | EP | disclosed |