Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11559604 | 0.86 | NOS2 (0.41) | CYP3A4CYP2D6CYP1A2CYP2C19ELANE | |
| SCHEMBL9592134 | 0.85 | NOS2 (0.37) | CYP3A4CYP2D6CYP1A2CYP2C19ELANE | |
| Hydrochloric Acid SCHEMBL6026726 | 0.83 | NOS2 (0.36) | CYP3A4CYP2D6CYP1A2CYP2C19NOS2 | |
| SCHEMBL1740647 | 0.83 | NOS2 (0.36) | CYP3A4CYP2D6CYP1A2CYP2C19ELANE | |
| SCHEMBL28695544 | 0.83 | NOS2 (0.36) | CYP3A4CYP2D6CYP1A2CYP2C19ELANE | |
| SCHEMBL11558591 | 0.83 | SLC6A2 (0.39) | CYP3A4CYP2D6CYP1A2CYP2C19NOS2 | |
| SCHEMBL11557434 | 0.83 | REN (0.35) | CYP3A4CYP2D6CYP1A2CYP2C19ELANE | |
| SCHEMBL7378973 | 0.82 | NOS2 (0.35) | CYP3A4CYP2D6CYP1A2CYP2C19ELANE | |
| SCHEMBL20839948 | 0.82 | NOS2 (0.35) | CYP3A4CYP2D6CYP1A2CYP2C19ELANE | |
| SCHEMBL499450 | 0.82 | NOS2 (0.39) | CYP3A4CYP2D6CYP1A2CYP2C19ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154937-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4128653-A | Reduction of blood pressure with carboxyalkylacyl-pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1978-12-05 | — | — | US | disclosed |
| US-4086338-A | HYPOTENSIVE AGENTS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1978-04-25 | — | — | US | disclosed |
| US-4052511-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1977-10-04 | — | — | US | disclosed |