Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11566899 | 0.80 | RECQL (0.36) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7214346 | 0.79 | PKM (0.33) | MEN1KMT2AKDM4EEPHX1 | |
| SCHEMBL15663547 | 0.79 | ALDH1A1 (0.32) | MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL11559618 | 0.74 | MEN1 (0.41) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9867672 | 0.73 | KDM4E (0.31) | KDM4E | |
| SCHEMBL17228791 | 0.73 | CTSK (0.43) | MEN1KMT2AGAA | |
| SCHEMBL11562636 | 0.72 | NPC1 (0.42) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL133932 | 0.72 | NPC1 (0.44) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7768332 | 0.72 | ALDH1A1 (0.46) | MEN1KMT2ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL16890324 | 0.72 | EPHX1 (0.52) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4156738-A | Ureidonitriles useful as antihypertensives | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-05-29 | — | — | US | disclosed |