Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 9/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11564844 | 0.86 | MEN1 (0.39) | TP53MEN1KMT2ARXFP1THRB | |
| SCHEMBL11560521 | 0.85 | CYP3A4 (0.44) | TP53MEN1KMT2APOLBRXFP1 | |
| SCHEMBL11558454 | 0.81 | MAPT (0.38) | TP53MEN1KMT2APOLBRXFP1 | |
| SCHEMBL11564982 | 0.79 | NPC1 (0.32) | TP53THRBMAPTLMNA | |
| SCHEMBL11564496 | 0.78 | LMNA (0.35) | TP53MEN1KMT2APOLBRXFP1 | |
| SCHEMBL11013664 | 0.78 | CYP3A4 (0.36) | TP53MEN1KMT2APOLBRXFP1 | |
| SCHEMBL11565451 | 0.78 | MEN1 (0.34) | TP53MEN1KMT2APOLBRXFP1 | |
| SCHEMBL11560945 | 0.77 | MAPT (0.39) | TP53MEN1KMT2APOLBRXFP1 | |
| SCHEMBL11563544 | 0.74 | THRB (0.34) | TP53MEN1KMT2APOLBRXFP1 | |
| SCHEMBL11486924 | 0.74 | CA1 (0.33) | TP53KMT2APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4165229-A | SUBSTITUTED THIADIAZOL-2-YLUREA | ELI LILLY AND COMPANY (US) | 1979-08-21 | — | — | US | disclosed |
| US-3972706-A | SUBSTITUTED THIADIAZOL-2-YL-UREAS | ELI LILLY AND COMPANY (US) | 1976-08-03 | — | — | US | disclosed |