Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11013664 | 0.84 | CYP3A4 (0.36) | LMNAMAPTTHRBCYP3A4TP53 | |
| SCHEMBL11558454 | 0.79 | MAPT (0.38) | LMNAMAPTTHRBTP53 | |
| SCHEMBL11564314 | 0.79 | TP53 (0.34) | LMNAMAPTTHRBTP53 | |
| SCHEMBL11486924 | 0.77 | CA1 (0.33) | RAB9ALMNACYP3A4TP53 | |
| SCHEMBL11564496 | 0.76 | LMNA (0.35) | LMNAMAPTTHRBTP53 | |
| SCHEMBL11564844 | 0.76 | MEN1 (0.39) | LMNAMAPTTHRBTP53 | |
| SCHEMBL11486958 | 0.76 | CYP3A4 (0.32) | LMNACYP3A4 | |
| SCHEMBL11560945 | 0.75 | MAPT (0.39) | LMNAMAPTTHRBTP53 | |
| SCHEMBL11563544 | 0.75 | THRB (0.34) | LMNAMAPTTHRBTP53 | |
| SCHEMBL11492782 | 0.73 | KDM4E (0.32) | RAB9AMAPTCYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4165229-A | SUBSTITUTED THIADIAZOL-2-YLUREA | ELI LILLY AND COMPANY (US) | 1979-08-21 | — | — | US | disclosed |
| US-3972706-A | SUBSTITUTED THIADIAZOL-2-YL-UREAS | ELI LILLY AND COMPANY (US) | 1976-08-03 | — | — | US | disclosed |